Human LIM homeobox transcription factor 1-beta / LMX1B ELISA Kit

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SKU:
HUFI01239
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
O60663
Sensitivity:
0.188ng/ml
Range:
0.313-20ng/ml
ELISA Type:
Competitive
Synonyms:
LMX1B, LIM homeobox transcription factor 1-beta, LMX-1.2, LIM, homeobox protein 1.2, LIM, homeobox protein LMX1B
Reactivity:
Human
Research Area:
Epigenetics and Nuclear Signaling

Description

Human LIM homeobox transcription factor 1-beta / LMX1B ELISA Kit

The protein encoded by LMX1B is a member of the LIM-homeodomain family, which includes two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. The protein is essential for normal limb development and the glomerular basement membrane, as well as the anterior segment of the eye, dopaminergic and serotonergic neurons. Nail-patella syndrome is associated with mutations in LMX1B. ForLMX1B, alternative spliced transcript variants have been identified that encode different isoforms. Nail-Patella Syndrome and Focal Segmental Glomerulosclerosis 10. are two examples of LMX1B-related diseases. The Dopaminergic Neurogenic Pathway, as well as Susceptibility to Sudden Infant Death Syndrome (SIDS), are two pathways associated with LMX1B.

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