Cytokines Recombinant Proteins

Human LIF Recombinant Protein (RPPB0736)

(No reviews yet) Write a Review
SKU:
RPPB0736
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P15018
Research Area:
Cytokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human LIF Recombinant Protein
Product Code:RPPB0736
Size:10µg
Species:Human
Target:LIF
Synonyms:D factor, MLPLI, HILDA, Emfilermin, Leukemia Inhibitory factor, Differentiation-stimulating factor, Melanoma-derived LPL inhibitor.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The LIF GST protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH 8.0) 1mM DTT, 50mM NaCl and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MHHHHHHMSP ILGYWKIKGL VQPTRLLLEY LEEKYEEHLY ERDEGDKWRN KKFELGLEFP NLPYYIDGDV KLTQSMAIIR YIADKHNMLG GCPKERAEIS MLEGAVLDIR YGVSRIAYSK DFETLKVDFL SKLPEMLKMF EDRLCHKTYL NGDHVTHPDF MLYDALDVVL YMDPMCLDAF PKLVCFKKRI EAIPQIDKYL KSSKYIAWPL QGWQATFGGG DHPPKSDLVP RGSHMSPLPI TPVNATCAIR HPCHNNLMNQ IRSQLAQLNG SANALFILYY TAQGEPFPNN LDKLCGPNVT DFPPFHANGT EKAKLVELYR IVVYLGTSLG NITRDQKILN PSALSLHSKL NATADILRGL LSNVLCRLCS KYHVGHVDVT YGPDTSGKDV FQKKKLGCQL LGKYKQIIAV LAQAF

Leukemia inhibitory factor, is a pleiotropic cytokine which is expressed by numerous cells including activated T lymphocytes, monocytes, mast cells and neuronal cells. LIF takes part in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and is a key player in immune tolerance at the maternal-fetal interface.

LIF produced in E.Coli is a single, non-glycosylated polypeptide chain containing 415 amino acids (23-202a.a.) and having a molecular mass of 47.2kDa.LIF is fused to a 236 amino acid His-GST tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
NCBI Summary:The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
UniProt Code:P15018
NCBI GenInfo Identifier:126279
NCBI Gene ID:3976
NCBI Accession:P15018.1
UniProt Secondary Accession:P15018,Q52LZ2, B2RCW7, B5MC23,
UniProt Related Accession:P15018
Molecular Weight:9,563 Da
NCBI Full Name:Leukemia inhibitory factor
NCBI Synonym Full Names:LIF, interleukin 6 family cytokine
NCBI Official Symbol:LIF��
NCBI Official Synonym Symbols:CDF; DIA; HILDA; MLPLI��
NCBI Protein Information:leukemia inhibitory factor
UniProt Protein Name:Leukemia inhibitory factor
UniProt Synonym Protein Names:Differentiation-stimulating factor; D factor; Melanoma-derived LPL inhibitor; MLPLI; INN: Emfilermin
Protein Family:Leukemia inhibitory factor
UniProt Gene Name:LIF��
View AllClose

0 Reviews

View AllClose

Related Products

Human LIF Recombinant Protein (RPES1092)

Human LIF Recombinant Protein (RPES1092)

system_update_altDatasheetHuman LIF Recombinant Protein Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It’s involved in growth pro