Human LGMN / Legumain ELISA Kit

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SKU:
HUFI01104
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
Q99538
Sensitivity:
0.094ng/ml
Range:
0.156-10ng/ml
ELISA Type:
Sandwich
Synonyms:
LGMN, Legumain, AEP, LGMN1, PRSC1, Protease, cysteine 1, Asparaginyl Endopeptidase, cysteine protease 1, legumain, protease, cysteine, 1, legumain
Reactivity:
Human
Research Area:
Cell Biology

Description

Human LGMN / Legumain ELISA Kit

LGMN/Legumain is a cysteine protease with a strict asparaginyl bond hydrolysis specificity. LGMN/Legumain may be involved in the lysosomal/endosomal processing of bacterial peptides and endogenous proteins for MHC class II presentation. The activation of enzymes appears to be autocatalytic and is triggered by an acidic pH. After monocytes differentiate into dendritic cells, protein expression occurs. Following lipopolysaccharide expression in mature dendritic cells, a fully mature, active enzyme is produced. Overexpression of this gene has been linked to a wide range of solid tumours. On chromosome 13, there is a pseudogene for this gene. Although several alternatively spliced transcript variants have been identified, only two have been proven to be biologically valid. Schistosomiasis and Cst3-Related Cerebral Amyloid Angiopathy are two diseases linked to LGMN.

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