Growth Factors & Cytokines Recombinant Proteins

Human LGALS8 Recombinant Protein (RPPB0288)

(No reviews yet) Write a Review
SKU:
RPPB0288
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O00214
Research Area:
Growth Factors & Cytokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human LGALS8 Recombinant Protein
Product Code:RPPB0288
Size:10µg
Species:Human
Target:LGALS8
Synonyms:Gal-8, PCTA1, Po66-CBP, Prostate carcinoma tumor antigen 1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The Galectin-8 His tag 0.5mg/ml protein solution contains 20mM Tris-HCl pH-8, 0.1M NaCl, 10% glycerol & 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MMLSLNNLQN IIYNPVIPFV GTIPDQLDPG TLIVIRGHVP SDADRFQVDL QNGSSMKPRA DVAFHFNPRF KRAGCIVCNT LINEKWGREE ITYDTPFKRE KSFEIVIMVL KDKFQVAVNG KHTLLYGHRI GPEKIDTLGI YGKVNIHSIG FSFSSDLQST QASSLELTEI SRENVPKSGT PQLRLPFAAR LNTPMGPGRT VVVKGEVNAN AKSFNVDLLA GKSKDIALHL NPRLNIKAFV RNSFLQESWG EEERNITSFP FSPGMYFEMI IYCDVREFKV AVNGVHSLEY KHRFKELSSI DTLEINGDIH LLEVRSW
Biological Activity:The ED50 for this effect is 5�10ug/ml. Measured by its ability to agglutinate human red blood cells corresponding to a specific activity of 100-200IU/mg.

LGALS8 is a prostate-specific antigen that is solely overexpressed in malignant tumors and thus is a supplementary specific identifier of malignancies. LGALS8 is part of the galectin gene family which facilitates both cell-cell and cell matrix interactions in a method parallel to the selectin subgroup of C-type lectins.

LGALS8 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 337 amino acids (1-317 a.a.) and having a molecular mass of 37.9 kDa. The LGALS8 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:galectin-8: 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell adhesion

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: cytosol; extracellular space; membrane

Molecular Function:carbohydrate binding; protein binding

NCBI Summary:This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:O00214
NCBI GenInfo Identifier:292495094
NCBI Gene ID:3964
NCBI Accession:O00214.4
UniProt Secondary Accession:O00214,O15215, Q5T3P5, Q5T3Q4, Q8TEV1, Q96B92, Q9BXC8 Q9H584, Q9H585, Q9UEZ6, Q9UP32, Q9UP33,
UniProt Related Accession:O00214
Molecular Weight:40,397 Da
NCBI Full Name:Galectin-8
NCBI Synonym Full Names:galectin 8
NCBI Official Symbol:LGALS8��
NCBI Official Synonym Symbols:Gal-8; PCTA1; PCTA-1; Po66-CBP��
NCBI Protein Information:galectin-8
UniProt Protein Name:Galectin-8
UniProt Synonym Protein Names:Po66 carbohydrate-binding protein; Po66-CBP; Prostate carcinoma tumor antigen 1; PCTA-1
Protein Family:Galectin
UniProt Gene Name:LGALS8��
UniProt Entry Name:LEG8_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products