Growth Factors & Cytokines Recombinant Proteins

Human LGALS10 Recombinant Protein (RPPB3857)

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SKU:
RPPB3857
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q05315
Research Area:
Growth Factors & Cytokines

Description

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Product Name:Human LGALS10 Recombinant Protein
Product Code:RPPB3857
Size:20µg
Species:Human
Target:LGALS10
Synonyms:Eosinophil lysophospholipase, Charcot-Leyden crystal protein, CLC, Galectin-10, Gal-10, Lysolecithin acylhydrolase, GAL10, LGALS10, LGALS10A.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:Galectin-10 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 0.1M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSLLPVPYTE AASLSTGSTV TIKGRPLACF LNEPYLQVDF HTEMKEESDI VFHFQVCFGR RVVMNSREYG AWKQQVESKN MPFQDGQEFE LSISVLPDKY QVMVNGQSSY TFDHRIKPEA VKMVQVWRDI SLTKFNVSYL KR

Eosinophil lysophospholipase (CLC) acts on biological membranes to regulate the multifunctional lysophospholipids. CLC is a lysophospholipase expressed in eosinophils and basophils. CLC hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. The CLC protein may possess carbohydrate or IgE-binding activities. CLC is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. CLC may be linked with inflammation and some myeloid leukemias.

LGALS10 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 162 amino acids (1-142 a.a.) and having a molecular mass of 18.6kDa.LGALS10 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).
NCBI Summary:Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]
UniProt Code:Q05315
NCBI GenInfo Identifier:317373429
NCBI Gene ID:1178
NCBI Accession:Q05315.3
UniProt Secondary Accession:Q05315,Q0VDE3, C5HZ13, C5HZ14,
UniProt Related Accession:Q05315
Molecular Weight:16,453 Da
NCBI Full Name:Galectin-10
NCBI Synonym Full Names:Charcot-Leyden crystal galectin
NCBI Official Symbol:CLC��
NCBI Official Synonym Symbols:GAL10; Gal-10; LGALS10; LGALS10A; LPPL_HUMAN��
NCBI Protein Information:galectin-10
UniProt Protein Name:Galectin-10
UniProt Synonym Protein Names:Charcot-Leyden crystal protein; CLC; Eosinophil lysophospholipase; Lysolecithin acylhydrolase
Protein Family:Clathrin
UniProt Gene Name:CLC��
UniProt Entry Name:LEG10_HUMAN
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