Human LEPR/CD295 Recombinant Protein (His tag)
- SKU:
- RPES5628
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
| Product Name: | Human LEPR/CD295 Recombinant Protein (His tag) |
| Product Code: | RPES5628 |
| Size: | 20µg |
| Species: | Human |
| Expression Host: | E.coli |
| Synonyms: | Leptin receptor, LEP-R, HuB219, OB receptor, OB-R, CD295, LEPR, DB, OBR |
| Mol Mass: | 34.21 kDa |
| AP Mol Mass: | 35 kDa |
| Tag: | N-His |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | Please contact us for more information. |
| Bio Activity: | Testing in progress |
| Sequence: | Phe 22-Val 333 |
| Accession: | P48357 |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation: | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution: | Please refer to the printed manual for detailed information. |
| Background: | Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Leptin Receptor/CD295 is a transmembrane catalytic receptors found on NPY/AgRP and alpha-MSH/CART neurons in hypothalamic nuclei. Leptin receptors (Ob-Rs) are coded for by one human gene that produces six different isoforms; Ob-Ra - Ob-Rf. Ob-Rs exist as constitutive dimers at physiological expression levels. Only the Ob-Rb isoform can transduce intracellular signals and does so through activation of the JAK2/STAT3, PI 3-K and MAPK signaling cascades. Activation of Ob-Rs mediates transcriptional regulation of the hypothalamic melanocortin pathway and downregulates endocannabinoid expression. Leptin acts via leptin receptors. Leptin resistance has been proposed as a pathophysiological mechanism of obesity. In obese individuals, Ob-Ra (which is involved in active transport of leptin across the blood-brain barrier) expression is downregulated and the individual may be unresponsive to leptin signals. Ob-R antagonists are of great interest in the development of pharmacological treatments for obesity. Mutations in Leptin Receptor/CD295 have been associated with obesity and pituitary dysfunction. |
Related Products
Human LEPR/CD295 Recombinant Protein (RPES4437)
system_update_altDatasheetHuman LEPR/CD295 Recombinant Protein Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activa
Human LEPR/CD295 Recombinant Protein (RPES4714)
system_update_altDatasheetHuman LEPR/CD295 Recombinant Protein Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activa
Human LEPR/CD295 Recombinant Protein (RPES1265)
Growth Factors & Cytokines Recombinant Proteins
system_update_altDatasheetHuman LEPR/CD295 Recombinant Protein The Leptin receptor is a member of the Class I cytokine receptor family. It mediates the activities of Leptin, a multi-functional ho
Human SDHA Recombinant Protein (His tag)
OverviewProduct Name:Human SDHA Recombinant Protein (His tag)Product Code:RPES5594Size:20µgSpecies:HumanExpress
Human KLK3 Recombinant Protein (His tag)
OverviewProduct Name:Human KLK3 Recombinant Protein (His tag)Product Code:RPES5551Size:20µgSpecies:HumanExpress