Human LECT2 Recombinant Protein (RPPB3856)
- SKU:
- RPPB3856
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O14960
Description
| Product Name: | Human LECT2 Recombinant Protein |
| Product Code: | RPPB3856 |
| Size: | 10µg |
| Species: | Human |
| Target: | LECT2 |
| Synonyms: | Leukocyte Cell-Derived Chemotaxin 2, Leukocyte Cell-Derived Chemotaxin-2, Chondromodulin-II, Chm-II, LECT-2, HLECT2, Chm2, LECT2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | LECT2 was filtered (0.4 �m) and lyophilized in 20mM Tris buffer, 50mM NaCl & pH 7.5. |
| Solubility: | It is recommended to add 200�l of deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. LECT2 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKHHHHHHASGPWANICAGK SSNEIRTCDR HGCGQYSAQR SQRPHQGVDI LCSAGSTVYA PFTGMIVGQE KPYQNKNAIN NGVRISGRGF CVKMFYIKPI KYKGPIKKGE KLGTLLPLQK VYPGIQSHVH IENCDSSDPT AYL |
Leukocyte Cell-Derived Chemotaxin 2 (LECT2) functions as a chemotactic factor to neutrophils. LECT2 stimulates the proliferation of chondrocytes and osteoblasts. LECT2 is strongly expressed in the liver and weakly in the testis. LECT2 is a secreted, 16kDa protein which serves as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. LECT2 protein has a high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in the LECT2 gene is linked with rheumatoid arthritis.
LECT2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Gly19-Leu151) containing 143 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 16kDa.
| UniProt Protein Function: | LECT2: Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation. Belongs to the LECT2/MIM-1 family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: cytoplasm; extracellular space Molecular Function:identical protein binding Biological Process: chemotaxis; skeletal development |
| NCBI Summary: | This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14960 |
| NCBI GenInfo Identifier: | 59806345 |
| NCBI Gene ID: | 3950 |
| NCBI Accession: | NP_002293.2 |
| UniProt Secondary Accession: | O14960,O14565, Q52M49, B2RA90, |
| UniProt Related Accession: | O14960 |
| Molecular Weight: | 16,390 Da |
| NCBI Full Name: | leukocyte cell-derived chemotaxin-2 |
| NCBI Synonym Full Names: | leukocyte cell derived chemotaxin 2 |
| NCBI Official Symbol: | LECT2�� |
| NCBI Official Synonym Symbols: | chm2; chm-II�� |
| NCBI Protein Information: | leukocyte cell-derived chemotaxin-2 |
| UniProt Protein Name: | Leukocyte cell-derived chemotaxin-2 |
| Protein Family: | Leukocyte cell-derived chemotaxin |
| UniProt Gene Name: | LECT2�� |
| UniProt Entry Name: | LECT2_HUMAN |
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