Enzymes Recombinant Proteins

Human LCN1 Recombinant Protein (RPPB1887)

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SKU:
RPPB1887
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P31025
Research Area:
Enzymes

Description

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Product Name:Human LCN1 Recombinant Protein
Product Code:RPPB1887
Size:20µg
Species:Human
Target:LCN1
Synonyms:Lipocalin-1, PMFA, TLC, TP, VEGP, Tear lipocalin, Tear prealbumin, Von Ebner gland protein, VEG protein.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:LCN1 protein solution (1mg/ml) containing Phosphate buffered saline (pH7.4), 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMHHLLA SDEEIQDVSG TWYLKAMTVD REFPEMNLES VTPMTLTTLEGGNLEAKVTM LISGRCQEVK AVLEKTDEPG KYTADGGKHV AYIIRSHVKD HYIFYCEGEL HGKPVRGVKLVGRDPKNNLE ALEDFEKAAG ARGLSTESIL IPRQSETCSP GSD

Lipocalin-1 (LCN1) belongs to the lipocalin family of small secretory proteins. Lipocalins are extracellular transport proteins, which bind to various hydrophobic ligands. LCN1 protein is the principal lipid binding protein in tears and is overproduced in response to numerous stimuli including infection and stress. LCN1 is a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome.

LCN1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 183 amino acids (19-176 a.a) and having a molecular mass of 20.1kDa. LCN1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:LCN1: Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket. Belongs to the calycin superfamily. Lipocalin family.
UniProt Protein Details:

Protein type:Secreted; Inhibitor; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: extracellular space; extracellular region

Molecular Function:cysteine protease inhibitor activity

Biological Process: long-chain fatty acid transport; retinal homeostasis; sensory perception of taste; response to stimulus; proteolysis; transmembrane transport

NCBI Summary:This gene encodes a member of the lipocalin family of small secretory proteins. Lipocalins are extracellular transport proteins that bind to a variety of hydrophobic ligands. The encoded protein is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. The encoded protein may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and two pseudogenes of this gene are also located on the long arm of chromosome 9. [provided by RefSeq, Nov 2011]
UniProt Code:P31025
NCBI GenInfo Identifier:401346
NCBI Gene ID:3933
NCBI Accession:P31025.1
UniProt Related Accession:P31025
Molecular Weight:
NCBI Full Name:Lipocalin-1
NCBI Synonym Full Names:lipocalin 1
NCBI Official Symbol:LCN1��
NCBI Official Synonym Symbols:TP; TLC; PMFA; VEGP��
NCBI Protein Information:lipocalin-1
UniProt Protein Name:Lipocalin-1
UniProt Synonym Protein Names:Tear lipocalin; Tlc; Tear prealbumin; TP; Von Ebner gland protein
Protein Family:Lipocalin
UniProt Gene Name:LCN1��
UniProt Entry Name:LCN1_HUMAN
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