Enzymes Recombinant Proteins
Human LCMT1 Recombinant Protein (RPPB1886)
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- SKU:
- RPPB1886
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UIC8
- Research Area:
- Enzymes
Description
| Product Name: | Human LCMT1 Recombinant Protein |
| Product Code: | RPPB1886 |
| Size: | 20µg |
| Species: | Human |
| Target: | LCMT1 |
| Synonyms: | Leucine carboxyl methyltransferase 1, LCMT1, LCMT, PPMT1, CGI-68. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The LCMT1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol, 1mM DTT and 0.15M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMATRQR ESSITSCCST SSCDADDEGV RGTCEDASLC KRFAVSIGYW HDPYIQHFVR LSKERKAPEI NRGYFARVHG VSQLIKAFLR KTECHCQIVN LGAGMDTTFW RLKDEDLLPS KYFEVDFPMI VTRKLHSIKC KPPLSSPILE LHSEDTLQMD GHILDSKRYA VIGADLRDLS ELEEKLKKCN MNTQLPTLLI AECVLVYMTP EQSANLLKWA ANSFERAMFI NYEQVNMGDR FGQIMIENLR RRQCDLAGVE TCKSLESQKE RLLSNGWETA SAVDMMELYN RLPRAEVSRI ESLEFLDEME LLEQLMRHYC LCWATKGGNE LGLKEITY |
LCMT1 is a member of the LCMT family, methyltransferase superfamily. LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A to form alpha-leucine ester residues.
LCMT1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 358 amino acids (1-334) and having a molecular mass of 41kDa.LCMT1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LCMT1: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. Belongs to the methyltransferase superfamily. LCMT family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - histidine; EC 2.1.1.233; Lipid Metabolism - androgen and estrogen; Methyltransferase; Other Amino Acids Metabolism - selenoamino acidChromosomal Location of Human Ortholog: 16p12.1Cellular Component: cytosolMolecular Function: protein binding; C-terminal protein carboxyl methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activityBiological Process: regulation of apoptosis; protein amino acid methylation; C-terminal protein amino acid methylation; protein modification process; negative regulation of protein complex assembly |
| UniProt Protein Details: | |
| NCBI Summary: | LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9UIC8 |
| NCBI GenInfo Identifier: | 74048545 |
| NCBI Gene ID: | 51451 |
| NCBI Accession: | NP_001027563.1 |
| UniProt Secondary Accession: | Q9UIC8,Q53FC5, Q96CI5, Q9H6I9, Q9NTG4, Q9Y378, A6NL89 A8K770 |
| UniProt Related Accession: | Q9UIC8 |
| Molecular Weight: | 32,172 Da |
| NCBI Full Name: | leucine carboxyl methyltransferase 1 isoform b |
| NCBI Synonym Full Names: | leucine carboxyl methyltransferase 1 |
| NCBI Official Symbol: | LCMT1�� |
| NCBI Official Synonym Symbols: | LCMT; PPMT1; CGI-68�� |
| NCBI Protein Information: | leucine carboxyl methyltransferase 1; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1; protein phosphatase methyltransferase 1; protein-leucine O-methyltransferase |
| UniProt Protein Name: | Leucine carboxyl methyltransferase 1 |
| UniProt Synonym Protein Names: | Protein-leucine O-methyltransferase; [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1 |
| Protein Family: | Leucine carboxyl methyltransferase |
| UniProt Gene Name: | LCMT1�� |
| UniProt Entry Name: | LCMT1_HUMAN |
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