Human LC3A/B Recombinant Protein (His tag)
- SKU:
- RPES5504
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
| Product Name: | Human LC3A/B Recombinant Protein (His tag) |
| Product Code: | RPES5504 |
| Size: | 20µg |
| Species: | Human |
| Expression Host: | E.coli |
| Synonyms: | ATG8F, Autophagy related protein LC3 A, Autophagy related ubiquitin like modifier LC3 A, Autophagy related ubiquitin like modifier LC3 B, LC3, MAP1 light chain 3 like protein 1, MAP1 light chain 3 like protein 2, MAP1A/1B light chain 3 A, MAP1A/1BLC3, MAP1ALC3, MAP |
| Mol Mass: | 13.64 kDa |
| AP Mol Mass: | 18 kDa |
| Tag: | N-10His |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | Please contact us for more information. |
| Bio Activity: | Testing in progress |
| Sequence: | Met 1-Val 125 |
| Accession: | Q9GZQ8 |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation: | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution: | Please refer to the printed manual for detailed information. |
| Background: | Ubiquitin-like modifier involved in formation of autophagosomal vacuoles. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. |
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