Human LANCL1 Recombinant Protein (RPPB3843)

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RPPB3843

Description

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Product Name:Human LANCL1 Recombinant Protein
Product Code:RPPB3843
Size:20µg
Species:Human
Target:LANCL1
Synonyms:GPR69A, p40, LanC-like protein 1, 40 kDa erythrocyte membrane protein, LANCL1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:LANCL1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 7.5), 0.15M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAQRAFP NPYADYNKSL AEGYFDAAGR LTPEFSQRLT NKIRELLQQM ERGLKSADPR DGTGYTGWAG IAVLYLHLYD VFGDPAYLQL AHGYVKQSLN CLTKRSITFL CGDAGPLAVA AVLYHKMNNE KQAEDCITRL IHLNKIDPHA PNEMLYGRIG YIYALLFVNK NFGVEKIPQS HIQQICETIL TSGENLARKR NFTAKSPLMY EWYQEYYVGA AHGLAGIYYY LMQPSLQVSQ GKLHSLVKPS VDYVCQLKFP SGNYPPCIGD NRDLLVHWCH GAPGVIYMLI QAYKVFREEK YLCDAYQCAD VIWQYGLLKK GYGLCHGSAG NAYAFLTLYN LTQDMKYLYR ACKFAEWCLE YGEHGCRTPD TPFSLFEGMA GTIYFLADLL VPTKARFPAF EL

LanC Lantibiotic Synthetase Component C-Like 1 (LANCL1) belongs to the LanC family although formerly considered a part of the G-proteincoupled receptor superfamily. LANCL1 takes part in the biosynthesis of antimicrobial peptides. LANCL1 functions as a peptide-modifying enzyme component in eukaryotic cells. LANCL1 participates in EPS8 signaling and binds glutathione.

LANCL1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 422 amino acids (1-399a.a) and having a molecular mass of 47.7kDa. LANCL1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:LANCL1: May play a role in EPS8 signaling. Binds glutathion. Belongs to the LanC-like protein family.Protein type: Receptor, misc.Chromosomal Location of Human Ortholog: 2q34Cellular Component: integral to plasma membraneMolecular Function: G-protein coupled receptor activity; glutathione binding; low-density lipoprotein receptor binding; protein binding; SH3 domain binding; zinc ion bindingBiological Process: G-protein coupled receptor protein signaling pathway
UniProt Protein Details:
NCBI Summary:This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
UniProt Code:O43813
NCBI GenInfo Identifier:212274337
NCBI Gene ID:10314
NCBI Accession:NP_001130046.1
UniProt Secondary Accession:O43813
UniProt Related Accession:O43813
Molecular Weight:
NCBI Full Name:lanC-like protein 1
NCBI Synonym Full Names:LanC like 1
NCBI Official Symbol:LANCL1��
NCBI Official Synonym Symbols:p40; GPR69A��
NCBI Protein Information:lanC-like protein 1
UniProt Protein Name:LanC-like protein 1
UniProt Synonym Protein Names:40 kDa erythrocyte membrane protein; p40
Protein Family:LanC-like protein
UniProt Gene Name:LANCL1��
UniProt Entry Name:LANC1_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O43813
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