Human LAMP2 Recombinant Protein (RPPB5901)
- SKU:
- RPPB5901
Description
| Product Name: | Human LAMP2 Recombinant Protein |
| Product Code: | RPPB5901 |
| Size: | 10µg |
| Species: | Human |
| Target: | LAMP2 |
| Synonyms: | Lysosomal-associated membrane protein 2, CD107b, LAMP-2, CD107 antigen-like family member B, LGP110, LAMP2. |
| Source: | Sf9 Insect cells |
| Formulation: | LAMP2 (0.94mg/ml) is supplied in 16mM HEPES buffer pH-8.0, 130mM NaCl and 20% Glycerol. |
| Stability: | Store LAMP2�at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�Avoid multiple freeze-thaw cycles. |
The protein encoded by LAMP2 belongs to a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands LAMP2 takes part in tumor cell metastasis and in addition has a role in the protection, maintenance, and adhesion of the lysosome. The effect of alternative splicing of this gene is multiple transcript variants encoding distinct proteins.
LAMP2 is a full-length cDNA coding for the human lysosomal-associated membrane protein 2 having a molecular mass of 42,488 Dalton (pH 5.88). LAMP2 protein is fused to a deca-histidine purification tag.
| UniProt Protein Function: | LAMP2: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. Defects in LAMP2 are the cause of Danon disease (DAND); also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. Belongs to the LAMP family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: Xq24 Cellular Component: phagocytic vesicle membrane; membrane; lysosome; lysosomal membrane; late endosome membrane; late endosome; plasma membrane; integral to membrane; platelet dense granule membrane Molecular Function:protein domain specific binding; enzyme binding Biological Process: platelet activation; platelet degranulation; protein stabilization; blood coagulation Disease: Danon Disease |
| NCBI Summary: | The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P13473 |
| NCBI GenInfo Identifier: | 1708854 |
| NCBI Gene ID: | 3920 |
| NCBI Accession: | P13473.2 |
| UniProt Secondary Accession: | P13473,Q16641, Q6Q3G8, Q96J30, Q99534, Q9UD93, A8K4X5 D3DTF0, |
| UniProt Related Accession: | P13473 |
| Molecular Weight: | 410 |
| NCBI Full Name: | Lysosome-associated membrane glycoprotein 2 |
| NCBI Synonym Full Names: | lysosomal-associated membrane protein 2 |
| NCBI Official Symbol: | LAMP2�� |
| NCBI Official Synonym Symbols: | LAMPB; CD107b; LAMP-2; LGP110�� |
| NCBI Protein Information: | lysosome-associated membrane glycoprotein 2; CD107 antigen-like family member B |
| UniProt Protein Name: | Lysosome-associated membrane glycoprotein 2 |
| UniProt Synonym Protein Names: | CD107 antigen-like family member B; CD_antigen: CD107b |
| Protein Family: | Lysosome-associated membrane glycoprotein |
| UniProt Gene Name: | LAMP2�� |
| UniProt Entry Name: | LAMP2_HUMAN |
Additional Information
Product Type: |
Recombinant Protein |
Species: |
Human |
Uniprot: |
P13473 |
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