Human LAMP2 Recombinant Protein (RPPB5901)

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SKU:
RPPB5901
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P13473

Description

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Product Name:Human LAMP2 Recombinant Protein
Product Code:RPPB5901
Size:10µg
Species:Human
Target:LAMP2
Synonyms:Lysosomal-associated membrane protein 2, CD107b, LAMP-2, CD107 antigen-like family member B, LGP110, LAMP2.
Source:Sf9 Insect cells
Formulation:LAMP2 (0.94mg/ml) is supplied in 16mM HEPES buffer pH-8.0, 130mM NaCl and 20% Glycerol.
Stability:Store LAMP2�at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�Avoid multiple freeze-thaw cycles.

The protein encoded by LAMP2 belongs to a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands LAMP2 takes part in tumor cell metastasis and in addition has a role in the protection, maintenance, and adhesion of the lysosome. The effect of alternative splicing of this gene is multiple transcript variants encoding distinct proteins.

LAMP2 is a full-length cDNA coding for the human lysosomal-associated membrane protein 2 having a molecular mass of 42,488 Dalton (pH 5.88). LAMP2 protein is fused to a deca-histidine purification tag.

UniProt Protein Function:LAMP2: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. Defects in LAMP2 are the cause of Danon disease (DAND); also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. Belongs to the LAMP family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: phagocytic vesicle membrane; membrane; lysosome; lysosomal membrane; late endosome membrane; late endosome; plasma membrane; integral to membrane; platelet dense granule membrane

Molecular Function:protein domain specific binding; enzyme binding

Biological Process: platelet activation; platelet degranulation; protein stabilization; blood coagulation

Disease: Danon Disease

NCBI Summary:The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
UniProt Code:P13473
NCBI GenInfo Identifier:1708854
NCBI Gene ID:3920
NCBI Accession:P13473.2
UniProt Secondary Accession:P13473,Q16641, Q6Q3G8, Q96J30, Q99534, Q9UD93, A8K4X5 D3DTF0,
UniProt Related Accession:P13473
Molecular Weight:410
NCBI Full Name:Lysosome-associated membrane glycoprotein 2
NCBI Synonym Full Names:lysosomal-associated membrane protein 2
NCBI Official Symbol:LAMP2��
NCBI Official Synonym Symbols:LAMPB; CD107b; LAMP-2; LGP110��
NCBI Protein Information:lysosome-associated membrane glycoprotein 2; CD107 antigen-like family member B
UniProt Protein Name:Lysosome-associated membrane glycoprotein 2
UniProt Synonym Protein Names:CD107 antigen-like family member B; CD_antigen: CD107b
Protein Family:Lysosome-associated membrane glycoprotein
UniProt Gene Name:LAMP2��
UniProt Entry Name:LAMP2_HUMAN
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