Human LAIR2/CD306 Recombinant Protein (RPES0329)
- SKU:
- RPES0329
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
system_update_altDatasheet
Human LAIR2/CD306 Recombinant Protein
CD306 is a cell surface glycoprotein from the leukocyte-associated immunoglobulinlike receptor 2 (LAIR2) family. It is a soluble receptor that binds to many collagen molecules in a hydroxyproline-dependent manner. LALR2 is an immunoglobulin superfamily member that was identified as similar to LAIR1, a mononuclear leukocyte inhibitory receptor. LAIR2 is thought to be secreted and may help modulate mucosal tolerance. Soluble LAIR2 competes with human LAIR1 for binding to collagens and LAIR1 cross-linking, limiting its inhibitory potential. LAIR2 is thought to act as an immunoregulatory protein. Human LAIR2/CD306 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | Human LAIR2/CD306 Recombinant Protein (RPES0329) |
| Product Code: | RPES0329 |
| Size: | 50µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | Leukocyte-Associated Immunoglobulin-Like Receptor 2, LAIR-2, CD306, LAIR2 |
| Accession: | NP_002279.2 |
| Sequence: | Met 1-Pro 152 |
| Fusion tag: | |
| Activity: | Measured by the ability of the immobilized protein to support the adhesion of HT-29 human colon adenocarcinoma cells. When 5 x 10E4 cells/well are added to recombiannt human LAIR2 coated plates (50 µg/ml with 100 ?l/well), >30% will adhere after 30 minutes at 37?. Optimal concentration depends on cell type as well as the application or research objectives. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human LAIR2 (NP_002279.2) (Met 1-Pro 152) was expressed and purified. |
| Purity: | > 93 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 14.1 kDa |
| AP Mol Mass: | 22 kDa |
| Formulation: | Lyophilized from sterile 50mM Tris, 0.7M NaCl, pH 8.0 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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