Immunology Recombinant Proteins
Human LAG3/CD223 Recombinant Protein (RPES1083)
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- SKU:
- RPES1083
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immunology
Description
system_update_altDatasheet
Human LAG3/CD223 Recombinant Protein
Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule; LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.
| Product Name: | Human LAG3/CD223 Recombinant Protein (RPES1083) |
| Product Code: | RPES1083 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Lymphocyte activation gene 3 protein,LAG3,LAG-3,Protein FDC,CD223,LAG-3 |
| Accession: | P18627 |
| Sequence: | Leu23-Leu450 |
| Fusion tag: | C-His |
| Activity: | Immobilized Human LAG-3-His at 5µg/ml(100 ?l/well) can bind Human FGL1-mFc(Cat: PKSH033679). The ED50 of Human LAG-3-His is 29 ng/ml. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human LAG3 Protein is produced by our Mammalian expression system and the target gene encoding Leu23-Leu450 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 47.2 kDa |
| AP Mol Mass: | 55-65 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS;2mMEDTA;pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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