Immunology Recombinant Proteins

Human LAG3/CD223 Recombinant Protein (RPES1064)

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RPES1064

Description

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Human LAG3/CD223 Recombinant Protein

Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule; LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.

Product Name:Human LAG3/CD223 Recombinant Protein (RPES1064)
Product Code:RPES1064
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Lymphocyte activation gene 3 protein,LAG3,LAG-3,Protein FDC,CD223,LAG-3
Accession:P18627
Sequence:Leu23-Leu450
Fusion tag:C-mFc
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human LAG3 Protein is produced by our Mammalian expression system and the target gene encoding Leu23-Leu450 is expressed with a mFc tag at the C-terminus.
Purity:> 95% as determined by reducing SDS-PAGE.
Mol Mass:72.7 kDa
AP Mol Mass:90 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of PBS; pH 7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immunology
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