Metabolism Recombinant Proteins

Human KYNU/Kynureninase Recombinant Protein (RPES0483)

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SKU:
RPES0483
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Metabolism

Description

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Human KYNU/Kynureninase Recombinant Protein

Kynureninase is an enzyme that cuts L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively, using pyridoxal phosphate as a substrate. Kynureninase is required for the generation of NAD cofactors from tryptophan via the kynurenine pathway. Two metabolic diseases, hydroxykynureninuria and limb defects syndrome 2, are linked to kynureninase. Human KYNU/Kynureninase Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.

Product Name:Human KYNU/Kynureninase Recombinant Protein (RPES0483)
Product Code:RPES0483
Size:10µg
Species:Human
Expressed Host:Baculovirus-Insect Cells
Synonyms:KYNUU
Accession:Q16719
Sequence:Met 1- Asn 465
Fusion tag:C-His
Activity:Measured by its ability to oxidize 3-hydroxykynurenine.The specific activity is > 200 pmoles/min/µg.
Endotoxin:<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:A DNA sequence encoding the human KYNU (Q16719) (Met 1- Asn 465) was expressed with a polyhistidine tag at the C-terminus.
Purity:> 92 % as determined by reducing SDS-PAGE.
Mol Mass:53.7 kDa
AP Mol Mass:47 kDa
Formulation:Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0, 25% gly
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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