Human KRT16 Recombinant Protein (RPPB3815)
- SKU:
- RPPB3815
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P08779
Description
| Product Name: | Human KRT16 Recombinant Protein |
| Product Code: | RPPB3815 |
| Size: | 20µg |
| Species: | Human |
| Target: | KRT16 |
| Synonyms: | Keratin, type I cytoskeletal 16, Cytokeratin 16, KRT16, Cytokeratin-16, CK-16, Keratin-16, K16, KRT16A, FNEPPK, K1CP, NEPPK. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The KRT16 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMTTCSRQ FTSSSSMKGS CGIGGGIGGG SSRISSVLAG GSCRAPSTYG GGLSVSSRFS SGGACGLGGG YGGGFSSSSS FGSGFGGGYG GGLGAGFGGG LGAGFGGGFA GGDGLLVGSE KVTMQNLNDR LASYLDKVRA LEEANADLEV KIRDWYQRQR PSEIKDYSPY FKTIEDLRNK IIAATIENAQ PILQIDNARL AADDFRTKYE HELALRQTVE ADVNGLRRVL DELTLARTDL EMQIEGLKEE LAYLRKNHEE EMLALRGQTG GDVNVEMDAA PGVDLSRILN EMRDQYEQMA EKNRRDAETW FLSKTEELNK EVASNSELVQ SSRSEVTELR RVLQGLEIEL QSQLSMKASL ENSLEETKGR YCMQLSQIQG LIGSVEEQLA QLRCEMEQQS QEYQILLDVK TRLEQEIATY RRLLEGEDAH LSSQQASGQS YSSREVFTSS SSSSSRQTRP ILKEQSSSSF SQGQSS |
Cytokeratin 16, also known as KRT16, is a member of the keratin gene family. KRT16 which acts as a regulator of innate immunity in response to skin barrier breach is required for some inflammatory checkpoint for the skin barrier maintenance. KRT16 is coexpressed with keratin 14 in a few epithelial tissues as esophagus, tongue, and hair follicles.
KRT16 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 496 amino acids (1-473) and having a molecular mass of 53.7 kDa.KRT16 is fused to a 23 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | K16: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6. K16 and K17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 17q21.2 Cellular Component: cytoskeleton; intermediate filament; nucleus Molecular Function:protein binding; structural constituent of cytoskeleton Biological Process: keratinocyte differentiation; cell proliferation; epidermis development; keratinization; morphogenesis of an epithelium; intermediate filament cytoskeleton organization and biogenesis; innate immune response; cytoskeleton organization and biogenesis; inflammatory response; negative regulation of cell migration; keratinocyte migration; hair cycle; aging Disease: Palmoplantar Keratoderma, Nonepidermolytic, Focal; Pachyonychia Congenita 1 |
| NCBI Summary: | The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08779 |
| NCBI GenInfo Identifier: | 23503075 |
| NCBI Gene ID: | 3868 |
| NCBI Accession: | P08779.4 |
| UniProt Secondary Accession: | P08779,P30654, Q16402, Q9UBG8, A8K488, |
| UniProt Related Accession: | P08779 |
| Molecular Weight: | 473 |
| NCBI Full Name: | Keratin, type I cytoskeletal 16 |
| NCBI Synonym Full Names: | keratin 16 |
| NCBI Official Symbol: | KRT16�� |
| NCBI Official Synonym Symbols: | K16; PC1; CK16; K1CP; NEPPK; FNEPPK; KRT16A�� |
| NCBI Protein Information: | keratin, type I cytoskeletal 16; CK-16; keratin-16; cytokeratin 16; cytokeratin-16; focal non-epidermolytic palmoplantar keratoderma |
| UniProt Protein Name: | Keratin, type I cytoskeletal 16 |
| UniProt Synonym Protein Names: | Cytokeratin-16; CK-16; Keratin-16; K16 |
| Protein Family: | Keratin |
| UniProt Gene Name: | KRT16�� |
| UniProt Entry Name: | K1C16_HUMAN |
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