Human KLRG1 Recombinant Protein (RPPB3806)
- SKU:
- RPPB3806
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96E93
Description
| Product Name: | Human KLRG1 Recombinant Protein |
| Product Code: | RPPB3806 |
| Size: | 10µg |
| Species: | Human |
| Target: | KLRG1 |
| Synonyms: | Killer cell lectin-like receptor subfamily G member 1, C-type lectin domain family 15 member A, ITIM-containing receptor MAFA-L, MAFA-like receptor, Mast cell function-associated antigen, KLRG1, CLEC15A, MAFA, MAFAL, 2F1, MAFA-L, MAFA-2F1, MAFA-LIKE. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | KLRG1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSLCQGSNY STCASCPSCP DRWMKYGNHC YYFSVEEKDW NSSLEFCLAR DSHLLVITDN QEMSLLQVFL SEAFCWIGLR NNSGWRWEDG SPLNFSRISS NSFVQTCGAI NKNGLQASSC EVPLHWVCKK VRL |
Killer Cell Lectin-like Receptor Subfamily G, Member 1 (KLRG1) is a member of the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Natural killer (NK) cells are lymphocytes which mediate lysis of certain tumor cells and virus-infected cells without previous activation. NK cells can also regulate specific humoral and cell-mediated immunity. The cell surface expression of KLRG1 is up-regulated by MHC class I molecules expression.
KLRG1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 153 amino acids (60-189 a.a) and having a molecular mass of 17kDa.KLRG1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | KLRG1: Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 12p13.31Cellular Component: plasma membrane; integral to membraneMolecular Function: receptor activity; carbohydrate bindingBiological Process: regulation of immune response; cell surface receptor linked signal transduction; innate immune response; cellular defense response; inflammatory response |
| UniProt Protein Details: | |
| NCBI Summary: | Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been reported, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96E93 |
| NCBI GenInfo Identifier: | 47717096 |
| NCBI Gene ID: | 10219 |
| NCBI Accession: | NP_005801.3 |
| UniProt Secondary Accession: | Q96E93,O43198, O75613, B7ZAM2 |
| UniProt Related Accession: | Q96E93 |
| Molecular Weight: | 21,206 Da |
| NCBI Full Name: | killer cell lectin-like receptor subfamily G member 1 |
| NCBI Synonym Full Names: | killer cell lectin-like receptor subfamily G, member 1 |
| NCBI Official Symbol: | KLRG1�� |
| NCBI Official Synonym Symbols: | 2F1; MAFA; MAFA-L; CLEC15A; MAFA-2F1; MAFA-LIKE�� |
| NCBI Protein Information: | killer cell lectin-like receptor subfamily G member 1; MAFA-like receptor; ITIM-containing receptor MAFA-L; C-type lectin domain family 15 member A; C-type lectin domain family 15, member A; mast cell function-associated antigen (ITIM-containing) |
| UniProt Protein Name: | Killer cell lectin-like receptor subfamily G member 1 |
| UniProt Synonym Protein Names: | C-type lectin domain family 15 member A; ITIM-containing receptor MAFA-L; MAFA-like receptor; Mast cell function-associated antigen |
| Protein Family: | |
| UniProt Gene Name: | KLRG1�� |
| UniProt Entry Name: | KLRG1_HUMAN |
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