Human KLRG1 Recombinant Protein (RPPB3806)

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SKU:
RPPB3806
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q96E93

Description

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Product Name:Human KLRG1 Recombinant Protein
Product Code:RPPB3806
Size:10µg
Species:Human
Target:KLRG1
Synonyms:Killer cell lectin-like receptor subfamily G member 1, C-type lectin domain family 15 member A, ITIM-containing receptor MAFA-L, MAFA-like receptor, Mast cell function-associated antigen, KLRG1, CLEC15A, MAFA, MAFAL, 2F1, MAFA-L, MAFA-2F1, MAFA-LIKE.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:KLRG1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSLCQGSNY STCASCPSCP DRWMKYGNHC YYFSVEEKDW NSSLEFCLAR DSHLLVITDN QEMSLLQVFL SEAFCWIGLR NNSGWRWEDG SPLNFSRISS NSFVQTCGAI NKNGLQASSC EVPLHWVCKK VRL

Killer Cell Lectin-like Receptor Subfamily G, Member 1 (KLRG1) is a member of the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Natural killer (NK) cells are lymphocytes which mediate lysis of certain tumor cells and virus-infected cells without previous activation. NK cells can also regulate specific humoral and cell-mediated immunity. The cell surface expression of KLRG1 is up-regulated by MHC class I molecules expression.

KLRG1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 153 amino acids (60-189 a.a) and having a molecular mass of 17kDa.KLRG1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:KLRG1: Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 12p13.31Cellular Component: plasma membrane; integral to membraneMolecular Function: receptor activity; carbohydrate bindingBiological Process: regulation of immune response; cell surface receptor linked signal transduction; innate immune response; cellular defense response; inflammatory response
UniProt Protein Details:
NCBI Summary:Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been reported, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]
UniProt Code:Q96E93
NCBI GenInfo Identifier:47717096
NCBI Gene ID:10219
NCBI Accession:NP_005801.3
UniProt Secondary Accession:Q96E93,O43198, O75613, B7ZAM2
UniProt Related Accession:Q96E93
Molecular Weight:21,206 Da
NCBI Full Name:killer cell lectin-like receptor subfamily G member 1
NCBI Synonym Full Names:killer cell lectin-like receptor subfamily G, member 1
NCBI Official Symbol:KLRG1��
NCBI Official Synonym Symbols:2F1; MAFA; MAFA-L; CLEC15A; MAFA-2F1; MAFA-LIKE��
NCBI Protein Information:killer cell lectin-like receptor subfamily G member 1; MAFA-like receptor; ITIM-containing receptor MAFA-L; C-type lectin domain family 15 member A; C-type lectin domain family 15, member A; mast cell function-associated antigen (ITIM-containing)
UniProt Protein Name:Killer cell lectin-like receptor subfamily G member 1
UniProt Synonym Protein Names:C-type lectin domain family 15 member A; ITIM-containing receptor MAFA-L; MAFA-like receptor; Mast cell function-associated antigen
Protein Family:
UniProt Gene Name:KLRG1��
UniProt Entry Name:KLRG1_HUMAN
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