Human KLRC2 Recombinant Protein (RPPB3803)

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RPPB3803

Description

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Product Name:Human KLRC2 Recombinant Protein
Product Code:RPPB3803
Size:10µg
Species:Human
Target:KLRC2
Synonyms:Killer cell lectin-like receptor subfamily C member 2, NKG2-C type II integral membrane protein, NKG2-C-activating NK receptor, CD159 antigen-like family member C, NK cell receptor C, NKG2C, CD159c.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The KLRC2 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMIPFLEQ NNFSPNTRTQ KARHCGHCPE EWITYSNSCY YIGKERRTWE ESLLACTSKN SSLLSIDNEE EMKFLASILP SSWIGVFRNS SHHPWVTING LAFKHKIKDS DNAELNCAVL QVNRLKSAQC GSSMIYHCKH KL

KLRC2 has a part as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. The group, designated KLRC (NKG2) are expressed mainly in natural killer (NK) cells and encodes a family of transmembrane proteins categorized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is situated inside the NK complex, a region which holds a few C-type lectin genes specially expressed on NK cells. KLRC2 alternative splice variants are known but their full-length nature is yet to be determined.

KLRC2 Human Recombinant produced in E. coli is a single polypeptide chain containing 162 amino acids (94-231) and having a molecular mass of 18.4 kDa.KLRC2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:KLRC2: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 12p13Cellular Component: integral to plasma membrane; plasma membrane; receptor complexMolecular Function: protein binding; transmembrane receptor activityBiological Process: cellular defense response; innate immune response; natural killer cell mediated immunity; signal transduction
UniProt Protein Details:
NCBI Summary:Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:P26717
NCBI GenInfo Identifier:20141529
NCBI Gene ID:3822
NCBI Accession:P26717.2
UniProt Secondary Accession:P26717,O43802, Q52M74, Q9NR42
UniProt Related Accession:P26717
Molecular Weight:26,072 Da
NCBI Full Name:NKG2-C type II integral membrane protein
NCBI Synonym Full Names:killer cell lectin like receptor C2
NCBI Official Symbol:KLRC2��
NCBI Official Synonym Symbols:NKG2C; CD159c; NKG2-C��
NCBI Protein Information:NKG2-C type II integral membrane protein
UniProt Protein Name:NKG2-C type II integral membrane protein
UniProt Synonym Protein Names:CD159 antigen-like family member C; NK cell receptor C; NKG2-C-activating NK receptor; CD_antigen: CD159c
Protein Family:NKG2-C type II integral membrane protein
UniProt Gene Name:KLRC2��
UniProt Entry Name:NKG2C_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P26717
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