Human KLRC1 Recombinant Protein (RPPB3802)

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SKU:
RPPB3802
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P26715

Description

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Product Name:Human KLRC1 Recombinant Protein
Product Code:RPPB3802
Size:5µg
Species:Human
Target:KLRC1
Synonyms:NKG2-A/NKG2-B type II integral membrane protein isoform NKG2-A, KLRC1, Killer Cell Lectin-Like Receptor Subfamily C, Member 1, KLRC1, CD159A, NKG2, NKG2A, CD159 antigen-like family member A, NK cell receptor A, NKG2-A/B-activating NK receptor.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:KLRC1 protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPPSTLIQR HNNSSLNTRT QKARHCGHCP EEWITYSNSC YYIGKERRTW EESLLACTSK NSSLLSIDNE EEMKFLSIIS PSSWIGVFRN SSHHPWVTMN GLAFKHEIKD SDNAELNCAV LQVNRLKSAQ CGSSIIYHCK HKLHHHHHH

Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1) is a part of the killer cell lectin-like receptor family. KLRC1 functions as a receptor for the detection of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. KLRC1 is also connects with CD94 and is expressed on NK cells and some activated T cell.

KLRC1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 149 amino acids (94-233a.a.) and having a molecular mass of 17.1kDa. KLRC1 is expressed with a 9 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
NCBI Summary:Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]
UniProt Code:P26715
NCBI GenInfo Identifier:317373399
NCBI Gene ID:3821
NCBI Accession:P26715.2
UniProt Related Accession:P26715
Molecular Weight:24,250 Da
NCBI Full Name:NKG2-A/NKG2-B type II integral membrane protein
NCBI Synonym Full Names:killer cell lectin like receptor C1
NCBI Official Symbol:KLRC1��
NCBI Official Synonym Symbols:NKG2; NKG2A; CD159A��
NCBI Protein Information:NKG2-A/NKG2-B type II integral membrane protein
UniProt Protein Name:NKG2-A/NKG2-B type II integral membrane protein
UniProt Synonym Protein Names:CD159 antigen-like family member A; NK cell receptor A; NKG2-A/B-activating NK receptor; CD_antigen: CD159a
UniProt Gene Name:KLRC1��
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