Enzymes Recombinant Proteins

Human KLK5 Recombinant Protein (RPPB1865)

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SKU:
RPPB1865
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9Y337
Research Area:
Enzymes

Description

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Product Name:Human KLK5 Recombinant Protein
Product Code:RPPB1865
Size:10µg
Species:Human
Target:KLK5
Synonyms:Kallikrein-5, Kallikrein-like protein 2, KLK-L2, Stratum corneum tryptic enzyme, KLK5, SCTE, UNQ570/PRO1132, KLKL2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The KLK5 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 2M Urea and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMIINGS DCDMHTQPWQ AALLLRPNQL YCGAVLVHPQ WLLTAAHCRK KVFRVRLGHY SLSPVYESGQ QMFQGVKSIP HPGYSHPGHS NDLMLIKLNR RIRPTKDVRP INVSSHCPSA GTKCLVSGWG TTKSPQVHFP KVLQCLNISV LSQKRCEDAY PRQIDDTMFC AGDKAGRDSC QGDSGGPVVC NGSLQGLVSW GDYPCARPNR PGVYTNLCKF TKWIQETIQA NS

Kallikrein-5 (KLK5) is a member of the serine protease family of proteolytic enzymes. KLK5 is expressed in various tissues including the salivary gland, stomach, uterus, lung, thymus, prostate, colon, brain, thyroid, and trachea. KLK5 expression is up-regulated by estrogens and progestins. KLK5 is secreted and may be involved in desquamation in the epidermis. Kallikreins which are a subgroup of serine proteases, have distinct physiological functions. Many kallikreins are associated with carcinogenesis and some have potential as novel cancer and other disease biomarkers. The KLK5 gene is one of the 15 kallikrein subfamily members located in a cluster on chromosome 19.

KLK5 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 252 amino acids (67-293) and having a molecular mass of 27.8kDa.KLK5 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:KLK5: May be involved in desquamation. Belongs to the peptidase S1 family. Kallikrein subfamily.
UniProt Protein Details:

Protein type:EC 3.4.21.-; Protease; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: extracellular space

Molecular Function:peptidase activity; protein binding; serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: epidermis development; positive regulation of G-protein coupled receptor protein signaling pathway; proteolysis

NCBI Summary:Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y337
NCBI GenInfo Identifier:296434569
NCBI Gene ID:25818
NCBI Accession:Q9Y337.2
UniProt Secondary Accession:Q9Y337,Q53ZR3, Q9HBG8,
UniProt Related Accession:Q9Y337
Molecular Weight:293
NCBI Full Name:Kallikrein-5
NCBI Synonym Full Names:kallikrein-related peptidase 5
NCBI Official Symbol:KLK5��
NCBI Official Synonym Symbols:SCTE; KLKL2; KLK-L2��
NCBI Protein Information:kallikrein-5; kallikrein 5; kallikrein-like protein 2; stratum corneum tryptic enzyme
UniProt Protein Name:Kallikrein-5
UniProt Synonym Protein Names:Kallikrein-like protein 2; KLK-L2; Stratum corneum tryptic enzyme
Protein Family:Kallikrein
UniProt Gene Name:KLK5��
UniProt Entry Name:KLK5_HUMAN
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