Enzymes Recombinant Proteins

Human KLK13 Recombinant Protein (RPPB1875)

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SKU:
RPPB1875
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9UKR3
Research Area:
Enzymes

Description

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Product Name:Human KLK13 Recombinant Protein
Product Code:RPPB1875
Size:5µg
Species:Human
Target:KLK13
Synonyms:Kallikrein-Related Peptidase 13, KLKL4, Kallikrein-LikeProtein 4, Kallikrein 13, KLK-L4, Kallikrein-Like Gene 4, Kallikrein-13, EC3.4.21.-, EC 3.4.21, Kallikrein-13.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:KLK13 protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:GGVSQESSKV LNTNGTSGFL PGGYTCFPHS QPWQAALLVQ GRLLCGGVLVHPKWVLTAAH CLKEGLKVYL GKHALGRVEA GEQVREVVHS IPHPEYRRSP THLNHDHDIM LLELQSPVQLTGYIQTLPLS HNNRLTPGTT CRVSGWGTTT SPQVNYPKTL QCANIQLRSD EECRQVYPGKITDNMLCAGT KEGGKDSCEG DSGGPLVCNR TLYGIVSWGD FPCGQPDRPGVYTRVSRYVL WIRETIRKYE TQQQKWLKGP QHHHHHH
Biological Activity:Specific activity is > 8,000 pmol/min/ug. One unitwill hydrolyze 1.0 pmole of BAEE toNa-Benzoyl-L-arginine per minute at pH8.0 at 25C.

Kallikreins are a subgroup of serine proteases having various physiological functions. Many kallikreins are implicated in carcinogenesis and some have potential of becoming novel cancer and other disease biomarkers. Kallikrein-13 (KLK13) is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. KLK13 gene expression is regulated by steroid hormones and may be useful as a marker for breast cancer.

KLK13 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 267 amino acids (17-277a.a.) andhaving a molecular mass of 29.7kDa.�(Molecular size on SDS-PAGE will appear atapproximately 28-40kDa).KLK13 is expressed with a 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:KLK13: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Vesicle; Secreted; Secreted, signal peptide; Protease; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: extracellular space; cytoplasm; extracellular region; secretory granule

Molecular Function:protein binding; hydrolase activity; serine-type endopeptidase activity

Biological Process: protein processing; proteolysis

NCBI Summary:Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UKR3
NCBI GenInfo Identifier:11496281
NCBI Gene ID:26085
NCBI Accession:NP_056411.1
UniProt Secondary Accession:Q9UKR3,Q86VI8, Q9Y433, A7UNK6,
UniProt Related Accession:Q9UKR3
Molecular Weight:13,986 Da
NCBI Full Name:kallikrein-13
NCBI Synonym Full Names:kallikrein-related peptidase 13
NCBI Official Symbol:KLK13��
NCBI Official Synonym Symbols:KLKL4; KLK-L4��
NCBI Protein Information:kallikrein-13; kallikrein 13; kallikrein-like gene 4; kallikrein-like protein 4
UniProt Protein Name:Kallikrein-13
UniProt Synonym Protein Names:Kallikrein-like protein 4; KLK-L4
Protein Family:Kallikrein
UniProt Gene Name:KLK13��
UniProt Entry Name:KLK13_HUMAN
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