Enzymes Recombinant Proteins

Human KLK11 Recombinant Protein (RPPB1873)

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SKU:
RPPB1873
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9UBX7
Research Area:
Enzymes

Description

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Product Name:Human KLK11 Recombinant Protein
Product Code:RPPB1873
Size:10µg
Species:Human
Target:KLK11
Synonyms:Kallikrein-11 isoform 1, KLK11, PRSS20, TLSP.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:KLK11 protein solution ( 0.5mg/m ) contains 50mM Tris-HCl (pH 7.5), 0.1M NaCl, 2mM CaCl2 and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADLETRIIKG FECKPHSQPW QAALFEKTRL LCGATLIAPR WLLTAAHCLK PRYIVHLGQH NLQKEEGCEQ� TRTATESFPH PGFNNSLPNK DHRNDIMLVK MASPVSITWA VRPLTLSSRC VTAGTSCLIS GWGSTSSPQL RLPHTLRCAN ITIIEHQKCE NAYPGNITDT MVCASVQEGG KDSCQGDSGG PLVCNQSLQG IISWGQDPCA ITRKPGVYTK VCKYVDWIQE TMKNNHHHHH H

Kallikreins are a subgroup of serine proteases having various physiological functions. Numerous kallikreins are involved in carcinogenesis. Kallikrein-11 (KLK11) which is a multifunctional protease is 1 of the 15 kallikrein subfamily members found in a cluster on chromosome 19. KLK11 cleaves synthetic peptides after arginine but not lysine residues.

KLK11 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 241 amino acids (19-250a.a.) and having a molecular mass of 26.7 kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).KLK11 is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:KLK11: Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.41

Cellular Component: extracellular space

Molecular Function:serine-type peptidase activity

NCBI Summary:Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]
UniProt Code:Q9UBX7
NCBI GenInfo Identifier:88984315
NCBI Gene ID:11012
NCBI Accession:Q9UBX7.2
UniProt Secondary Accession:Q9UBX7,O75837, Q0WXX5, Q8IXD7, Q9NS65,
UniProt Related Accession:Q9UBX7
Molecular Weight:31kDa
NCBI Full Name:Kallikrein-11
NCBI Synonym Full Names:kallikrein related peptidase 11
NCBI Official Symbol:KLK11��
NCBI Official Synonym Symbols:TLSP; PRSS20��
NCBI Protein Information:kallikrein-11
UniProt Protein Name:Kallikrein-11
UniProt Synonym Protein Names:Hippostasin; Serine protease 20; Trypsin-like protease
Protein Family:Kallikrein
UniProt Gene Name:KLK11��
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