Enzymes Recombinant Proteins

Human KLK10 Recombinant Protein (RPPB1870)

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SKU:
RPPB1870
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O43240
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human KLK10 Recombinant Protein
Product Code:RPPB1870
Size:20µg
Species:Human
Target:KLK10
Synonyms:Kallikrein-Related Peptidase 10, KLK10, PRSSL1, NES1, Normal Epithelial Cell-Specific 1, Protease Serine-Like 1, Kallikrein 10, Breast Normal Epithelial Cell Associated Serine Protease, kallikrein-10, Protease, Serine-Like 1, EC 3.4.21.- , EC 3.4.21, EC 3.4.21.74.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The KLK10 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSALLPQND TRLDPEAYGS PCARGSQPWQ VSLFNGLSFH CAGVLVDQSW VLTAAHCGNK PLWARVGDDH LLLLQGEQLR RTTRSVVHPK YHQGSGPILP RRTDEHDLML LKLARPVVLG PRVRALQLPY RCAQPGDQCQ VAGWGTTAAR RVKYNKGLTC SSITILSPKE CEVFYPGVVT NNMICAGLDR GQDPCQSDSG GPLVCDETLQ GILSWGVYPC GSAQHPAVYT QICKYMSWIN KVIRSN

Kallikrein-10 (KLK10) is one of the 15 kallikrein subfamily members located in a cluster on chromosome 19. Kallikreins are a subgroup of serine proteases having various physiological functions. KLK10 is secreted and has a role in suppression of tumorigenesis in breast and prostate cancers.

KLK10 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 266 amino acids (34-276) and having a molecular mass of 29.1kDa.KLK10 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:KLK10: Has a tumor-suppressor role for NES1 in breast and prostate cancer. Belongs to the peptidase S1 family. Kallikrein subfamily.
UniProt Protein Details:

Protein type:Secreted; Tumor suppressor; Protease; Secreted, signal peptide; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 19q13

Molecular Function:serine-type peptidase activity

NCBI Summary:Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
UniProt Code:O43240
NCBI GenInfo Identifier:317373432
NCBI Gene ID:5655
NCBI Accession:O43240.3
UniProt Secondary Accession:O43240,Q53YL3, Q99920, Q9GZW9, A6NC12,
UniProt Related Accession:O43240
Molecular Weight:30,170 Da
NCBI Full Name:Kallikrein-10
NCBI Synonym Full Names:kallikrein related peptidase 10
NCBI Official Symbol:KLK10��
NCBI Official Synonym Symbols:NES1; PRSSL1��
NCBI Protein Information:kallikrein-10
UniProt Protein Name:Kallikrein-10
UniProt Synonym Protein Names:Normal epithelial cell-specific 1; Protease serine-like 1
Protein Family:Kallikrein
UniProt Gene Name:KLK10��
UniProt Entry Name:KLK10_HUMAN
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system_update_altDatasheetHuman Kallikrein 10/KLK10 Recombinant Protein Kallikreins are a subgroup of Serine Proteases having diverse physiological functions. Growing evidence suggests that many