Human KLF7 Recombinant Protein (RPPB3797)

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SKU:
RPPB3797
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O75840

Description

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Product Name:Human KLF7 Recombinant Protein
Product Code:RPPB3797
Size:20µg
Species:Human
Target:KLF7
Synonyms:UKLF, Krueppel-like factor 7, Ubiquitous krueppel-like factor, KLF7.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The KLF7 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMDVLASY SIFQELQLVH DTGYFSALPS LEETWQQTCL ELERYLQTEP RRISETFGED LDCFLHASPP PCIEESFRRL DPLLLPVEAA ICEKSSAVDI LLSRDKLLSE TCLSLQPASS SLDSYTAVNQ AQLNAVTSLT PPSSPELSRH LVKTSQTLSA VDGTVTLKLV AKKAALSSVK VGGVATAAAA VTAAGAVKSG QSDSDQGGLG AEACPENKKR VHRCQFNGCR KVYTKSSHLK AHQRTHTGEK PYKCSWEGCE WRFARSDELT RHYRKHTGAK PFKCNHCDRC FSRSDHLALH MKRHI

Kruppel-Like Factor 7 (KLF7) is a part of the Kruppel-like transcriptional regulator family whose members regulate cell proliferation, differentiation and survival and contain 3 C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. KLF7 contributes to the progression of type 2 diabetes by inhibiting�hormone expression and secretion in pancreatic beta-cells and also by deregulating adipocytokine secretion in adipocytes.

KLF7 Human Recombinant produced in E. coli is a single polypeptide chain containing 325 amino acids (1-302) and having a molecular mass of 35.8kDa. KLF7 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:KLF7: Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence. Belongs to the krueppel C2H2-type zinc-finger protein family.
UniProt Protein Details:

Protein type:DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: nucleus

Molecular Function:DNA binding; zinc ion binding; transcription coactivator activity; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; axon guidance; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; dendrite morphogenesis

NCBI Summary:The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
UniProt Code:O75840
NCBI GenInfo Identifier:401709918
NCBI Gene ID:8609
NCBI Accession:NP_001257871.1
UniProt Secondary Accession:O75840,Q7Z3H8, Q96E51, B2RB03, B7Z4F7, C9JF04, E7EWH1 L0R4P2,
UniProt Related Accession:O75840
Molecular Weight:33kd
NCBI Full Name:Krueppel-like factor 7 isoform 2
NCBI Synonym Full Names:Kruppel-like factor 7 (ubiquitous)
NCBI Official Symbol:KLF7��
NCBI Official Synonym Symbols:UKLF��
NCBI Protein Information:Krueppel-like factor 7
UniProt Protein Name:Krueppel-like factor 7
UniProt Synonym Protein Names:Ubiquitous krueppel-like factor
Protein Family:Krueppel-like factor
UniProt Gene Name:KLF7��
UniProt Entry Name:KLF7_HUMAN
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