Human KIR2DL4/CD158D Recombinant Protein (RPES3004)
- SKU:
- RPES3004
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
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Human KIR2DL4/CD158D Recombinant Protein
Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4) is a Single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.
| Product Name: | Human KIR2DL4/CD158D Recombinant Protein (RPES3004) |
| Product Code: | RPES3004 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Killer Cell Immunoglobulin-Like Receptor 2DL4, CD158 Antigen-Like Family Member D, G9P, Killer Cell Inhibitory Receptor 103AS, KIR-103AS, MHC Class I NK Cell Receptor KIR103AS, CD158d, KIR2DL4, CD158D, KIR103AS |
| Accession: | Q99706 |
| Sequence: | Trp22-His242 |
| Fusion tag: | C-6His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Killer cell immunoglobulin-like receptor 2DL4 is produced by our Mammalian expression system and the target gene encoding Trp22-His242 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 90 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 25.3 kDa |
| AP Mol Mass: | 37 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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