Enzymes Recombinant Proteins

Human KDSR Recombinant Protein (RPPB1857)

(No reviews yet) Write a Review
SKU:
RPPB1857

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human KDSR Recombinant Protein
Product Code:RPPB1857
Size:20µg
Species:Human
Target:KDSR
Synonyms:3-ketodihydrosphingosine reductase, KDS reductase, 3-dehydrosphinganine reductase, Follicular variant translocation protein 1, FVT-1, KDSR, FVT1, DHSR, SDR35C1, FLJ36555, FLJ92680.
Source:Escherichia Coli
Physical Appearance:The�KDSR is supplied as a sterile filtered colorless solution.
Formulation:The KDSR solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol, 0.1M NaCl and 0.1mM PMSF.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:KDSR purity was found to be greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MKPLALPGAH VVVTGGSSGI GKCIAIECYK QGAFITLVAR NEDKLLQAKK EIEMHSINDK QVVLCISVDV SQDYNQVENV IKQAQEKLGP VDMLVNCAGM AVSGKFEDLE VSTFERLMSI NYLGSVYPSR AVITTMKERR VGRIVFVSSQ AGQLGLFGFT AYSASKFAIR GLAEALQMEV KPYNVYITVA YPPDTDTPGF AEENRTKPLE TRLISETTSV CKPEQVAKQI VKDAIQGNFN SSLGSD

3-ketodihydrosphingosine reductase (KDSR) is a 332 amino acid multi-pass membrane protein which localizes to the ER and is a member of the short-chain dehydrogenases/reductases (SDR) family. KDSR is a secreted protein that is weakly expressed in hematopoietic tissue. Furthermore, KDSR catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). The putative active site residues of KDSR are found on the cytosolic side of the endoplasmic reticulum membrane. Chromosomal rearrangement in the KDSR gene is a cause of follicular lymphoma, aka type II chronic lymphatic leukemia.

KDSR Human Recombinant fused with a�21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing�266 amino acids (26-270 a.a.) and having a molecular mass of 29kDa. The KDSR is purified by proprietary chromatographic techniques.

UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. [provided by RefSeq, Jul 2008]
UniProt Code:Q06136
NCBI GenInfo Identifier:544358
NCBI Gene ID:2531
NCBI Accession:Q06136.1
UniProt Secondary Accession:Q06136
UniProt Related Accession:Q06136
Molecular Weight:29kDa
NCBI Full Name:3-ketodihydrosphingosine reductase
NCBI Synonym Full Names:3-ketodihydrosphingosine reductase
NCBI Official Symbol:KDSR��
NCBI Official Synonym Symbols:DHSR; FVT1; EKVP4; SDR35C1��
NCBI Protein Information:3-ketodihydrosphingosine reductase
UniProt Protein Name:
UniProt Synonym Protein Names:
Protein Family:
UniProt Gene Name:
UniProt Entry Name:
View AllClose

Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q06136
Research Area:
Enzymes
View AllClose

Related Products