Human KCTD5 Recombinant Protein (RPPB3778)

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SKU:
RPPB3778
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NXV2

Description

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Product Name:Human KCTD5 Recombinant Protein
Product Code:RPPB3778
Size:10µg
Species:Human
Target:KCTD5
Synonyms:BTB/POZ domain-containing protein KCTD5, KCTD5.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The KCTD5 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 40% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAENHCE LLSPARGGIG AGLGGGLCRR CSAGLGALAQ RPGSVSKWVR LNVGGTYFLT TRQTLCRDPK SFLYRLCQAD PDLDSDKDET GAYLIDRDPT YFGPVLNYLR HGKLVINKDL AEEGVLEEAE FYNITSLIKL VKDKIRERDS KTSQVPVKHV YRVLQCQEEE LTQMVSTMSD GWKFEQLVSI GSSYNYGNED QAEFLCVVSK ELHNTPYGTA SEPSEKAKIL QERGSRM

BTB/POZ domain-containing protein KCTD5 (KCTD5), is a 234 amino acid protein which localizes mainly in the cytoplasm however translocates to the nucleus on interaction with REP proteins. The expression of KCTD5 is up regulated post-transcriptionally in peripheral blood lymphocytes stimulated via the T-cell receptor. KCTD5 interacts particularly with cullin3, attaches ubiquitinated proteins, and created oligomers through its BTB domain.

KCTD5 Human Recombinant produced in E. coli is a single polypeptide chain containing 257 amino acids (1-234) and having a molecular mass of 28.5 kDa. KCTD5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:KCTD5: Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4.Protein type: Channel, potassiumChromosomal Location of Human Ortholog: 16p13.3Cellular Component: cytosol; nucleusMolecular Function: protein binding; protein complex bindingBiological Process: viral reproduction; protein homooligomerization
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9NXV2
NCBI GenInfo Identifier:9506651
NCBI Gene ID:54442
NCBI Accession:NP_061865.1
UniProt Secondary Accession:Q9NXV2,D3DU96
UniProt Related Accession:Q9NXV2
Molecular Weight:26,093 Da
NCBI Full Name:BTB/POZ domain-containing protein KCTD5
NCBI Synonym Full Names:potassium channel tetramerization domain containing 5
NCBI Official Symbol:KCTD5��
NCBI Official Synonym Symbols:
NCBI Protein Information:BTB/POZ domain-containing protein KCTD5; potassium channel tetramerisation domain containing 5
UniProt Protein Name:BTB/POZ domain-containing protein KCTD5
UniProt Synonym Protein Names:
Protein Family:BTB/POZ domain-containing protein
UniProt Gene Name:KCTD5��
UniProt Entry Name:KCTD5_HUMAN
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