Enzymes Recombinant Proteins

Human KAT2A Recombinant Protein (RPPB1856)

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RPPB1856

Description

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Product Name:Human KAT2A Recombinant Protein
Product Code:RPPB1856
Size:20µg
Species:Human
Target:KAT2A
Synonyms:Histone acetyltransferase KAT2A, General control of amino acid synthesis protein 5-like 2, Histone acetyltransferase GCN5, HsGCN5, Lysine acetyltransferase 2A, STAF97, KAT2A, GCN5, GCN5L2, HGCN5, PCAF-b.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:KAT2A protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 5mM DTT, 40% glycerol, 200mM NaCl and 1mM EDTA.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGGGSNSSLS LDSAGAEPMP GEKRTLPENL TLEDAKRLRV MGDIPMELVN EVMLTITDPA AMLGPETSLL SANAARDETA RLEERRGIIE FHVIGNSLTP KANRRVLLWL VGLQNVFSHQ LPRMPKEYIA RLVFDPKHKT LALIKDGRVI GGICFRMFPT QGFTEIVFCA VTSNEQVKGY GTHLMNHLKE YHIKHNILYF LTYADEYAIG YFKKQGFSKD IKVPKSRYLG YIKDYEGATL MECELNPRIP YTELSHIIKK QKEIIKKLIE RKQAQIRKVY PGLSCFKEGV RQIPVESVPG IRETGWKPLG KEKGKELKDP DQLYTTLKNL LAQIKSHPSA WPFMEPVKKS EAPDYYEVIR FPIDLKTMTE RLRSRYYVTR KLFVADLQRV IANCREYNPP DSEYCRCASA LEKFFYFKLK EGGLIDK

General control of amino acid synthesis protein 5 like 2 (KAT2A) is a member of the GCN5 family. KAT2A functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. KAT2A interacts with Ku70, TAF9, transcription initiation protein SPT3 homolog, TADA2L, Ku80 and DDB1.

KAT2A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 447 amino acids (411-837 a.a) and having a molecular mass of 51.1kDa.KAT2A is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:GCN5: an ubiquitous histone acetyltransferase that promotes transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Interacts with P300, CBP, ADA2, and is a component of the TFTC-HAT complex. Two splice variant isoforms have been described.
UniProt Protein Details:

Protein type:EC 2.3.1.48; Acetyltransferase

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: extracellular space; nucleoplasm

Molecular Function:H3 histone acetyltransferase activity; histone acetyltransferase activity; histone deacetylase binding; protein binding; transcription coactivator activity; transcription factor binding

Biological Process: chromatin remodeling; histone deubiquitination; positive regulation of gene expression, epigenetic; regulation of protein stability; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter

NCBI Summary:KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]
UniProt Code:Q92830
NCBI GenInfo Identifier:209572743
NCBI Gene ID:2648
NCBI Accession:Q92830.3
UniProt Secondary Accession:Q92830,Q8N1A2, Q9UCW1,
UniProt Related Accession:Q92830
Molecular Weight:48,921 Da
NCBI Full Name:Histone acetyltransferase KAT2A
NCBI Synonym Full Names:lysine acetyltransferase 2A
NCBI Official Symbol:KAT2A��
NCBI Official Synonym Symbols:GCN5; hGCN5; GCN5L2; PCAF-b��
NCBI Protein Information:histone acetyltransferase KAT2A
UniProt Protein Name:Histone acetyltransferase KAT2A
UniProt Synonym Protein Names:General control of amino acid synthesis protein 5-like 2; Histone acetyltransferase GCN5; HsGCN5; Lysine acetyltransferase 2A; STAF97
Protein Family:Histone acetyltransferase
UniProt Gene Name:KAT2A��
UniProt Entry Name:KAT2A_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q92830
Research Area:
Enzymes
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