Human JAM-A/F11R Recombinant Protein (RPES0523)
- SKU:
- RPES0523
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
system_update_altDatasheet
Human JAM-A/F11R Recombinant Protein
Junctional adhesion molecule-A (JAM-A); also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321); is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells; as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1; involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily; JAM-A protein involves in platelet adhesion; secretion and aggregation; and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition; it may be a potential therapeutic target for breast cancer.
| Product Name: | Human JAM-A/F11R Recombinant Protein (RPES0523) |
| Product Code: | RPES0523 |
| Size: | 50µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | Junctional Adhesion Molecule A, JAM-A, Junctional Adhesion Molecule 1, JAM-1, Platelet F11 Receptor, Platelet Adhesion Molecule 1, PAM-1, CD321, F11R, JAM1, JCAM,JAMA,JCAM,KAT |
| Accession: | NP_058642.1 |
| Sequence: | Met 1-Ala 242 |
| Fusion tag: | C-Fc |
| Activity: | Measured by the ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells.When 8 x 104 cells/well are added to JAM-A-Fc coated plates (2.5µg/mL; 100 ?L/well)in the presence of 20 ng/mL PMA; approximately 30-40% will adhere after 30 minutes at 37?. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the extracellular domain (Met 1-Ala 242) of human JAM-A (NP_058642.1) precursor was expressed with the fused Fc region of human IgG1 at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 50 kDa |
| AP Mol Mass: | 61 kDa |
| Formulation: | Lyophilized from sterile 100mM Glycine; 10mM NaCl; 50mM Tris; pH 7.5 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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