Cytokines Recombinant Proteins

Human IRF 2 Recombinant Protein (RPPB0412)

(No reviews yet) Write a Review
SKU:
RPPB0412

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human IRF 2 Recombinant Protein
Product Code:RPPB0412
Size:20µg
Species:Human
Target:IRF 2
Synonyms:IRF-2, IRF2, MAR, DKFZp686F0244, IFN regulatory factor 2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:1 mg/ml in 20mM Tris pH-8, 1mM DTT and 10% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MPVERMRMRP WLEEQINSNT IPGLKWLNKE KKIFQIPWMHAARHGWDVEK DAPLFRNWAI HTGKHQPGVD KPDPKTWKAN FRCAMNSLPD IEEVKDKSIKKGNNAFRVYR MLP

IFN regulatory factor 2 is a member of the IFN regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of IFNs alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. IRF2 binds to the upstream regulatory region of type-1 IFN and IFN-inducible MHC class-1 genes (the IFN consensus sequence (ics) and represses those genes.

IFN Regulatory Factor-2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 133 amino acids (1-113) with a His Tag of 20 aa, and having a molecular mass of 15 kDa.The IRF2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:IRF2: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction acetylates IRF2 and regulates IRF2-dependent H4 promoter activity. By viruses and IFN. Expressed throughout the epithelium of the colon. Also expressed in lamina propria. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 4q34.1-q35.1

Cellular Component: nucleoplasm; focal adhesion; cytoplasm; cytosol

Molecular Function:protein binding; DNA binding; transcription factor activity

Biological Process: cell proliferation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; blood coagulation

NCBI Summary:IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]
UniProt Code:P14316
NCBI GenInfo Identifier:20141499
NCBI Gene ID:3660
NCBI Accession:P14316.2
UniProt Secondary Accession:P14316,Q6IAS7, Q96B99, D6RCK5, H0Y8S3,
UniProt Related Accession:P14316
Molecular Weight:39,156 Da
NCBI Full Name:Interferon regulatory factor 2
NCBI Synonym Full Names:interferon regulatory factor 2
NCBI Official Symbol:IRF2��
NCBI Official Synonym Symbols:IRF-2��
NCBI Protein Information:interferon regulatory factor 2
UniProt Protein Name:Interferon regulatory factor 2
Protein Family:Interferon regulatory factor
UniProt Gene Name:IRF2��
UniProt Entry Name:IRF2_HUMAN
View AllClose

Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P14316
Research Area:
Cytokines
View AllClose

Related Products