Chemokines Recombinant Proteins

Human IP 10 Recombinant Protein (RPPB1171)

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SKU:
RPPB1171
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P02778
Research Area:
Chemokines

Description

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Product Name:Human IP 10 Recombinant Protein
Product Code:RPPB1171
Size:25µg
Species:Human
Target:IP 10
Synonyms:Small inducible cytokine B10, CXCL10, 10 kDa interferon-gamma-induced protein, Gamma-IP10, IP-10, chemokine (C-X-C motif) ligand 10, C7, IFI10, INP10, crg-2, mob-1, SCYB10, gIP-10.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:IP-10 His is supplied in 10mM Tris HCl pH8, 1mM EDTA and 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Purity:Greater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.

Chemokine (C-X-C motif) ligand 10 (CXCL10) is a small cytokine belonging to the CXC chemokine family that is also known as 10 kDa interferon-gamma-induced protein. These cell types include monocytes, endothelial cellsand fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytesand T cells, promotion of T cell adhesion to endothelial cells, anti tumor activity, and inhibition of bone marrow colony formation and angiogenesis. The gene for CXCL10 is located on human chromosome 4in a cluster among several other CXC chemokines. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. The three-dimensional crystal structure of this chemokine has been determined under 3 different conditions to a resolution of up to 1.92A.

IP-10 His Tag Human Recombinant ?produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 77 amino acids fragment (22-98) and having a total molecular mass of 8.5 kDa with an amino-terminal hexahistidine tag. The IP-10 His is purified by proprietary chromatographic techniques.

UniProt Protein Function:CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.
UniProt Protein Details:

Protein type:Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region; external side of plasma membrane

Molecular Function:heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity; cAMP-dependent protein kinase regulator activity; receptor binding

Biological Process: muscle development; blood circulation; protein secretion; positive regulation of leukocyte chemotaxis; positive regulation of cAMP metabolic process; signal transduction; chemotaxis; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; response to vitamin D; cell surface receptor linked signal transduction; cell-cell signaling; positive regulation of cell proliferation; response to gamma radiation; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of release of sequestered calcium ion into cytosol; response to cold; negative regulation of myoblast differentiation; inflammatory response; regulation of protein kinase activity; defense response to virus

NCBI Summary:This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]
UniProt Code:P02778
NCBI GenInfo Identifier:21542456
NCBI Gene ID:3627
NCBI Accession:P02778.2
UniProt Secondary Accession:P02778,Q96QJ5,
UniProt Related Accession:P02778
Molecular Weight:10,881 Da
NCBI Full Name:C-X-C motif chemokine 10
NCBI Synonym Full Names:chemokine (C-X-C motif) ligand 10
NCBI Official Symbol:CXCL10��
NCBI Official Synonym Symbols:C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10��
NCBI Protein Information:C-X-C motif chemokine 10; gamma IP10; gamma-IP10; small-inducible cytokine B10; interferon-inducible cytokine IP-10; 10 kDa interferon gamma-induced protein; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine subfamily B (Cys-X-Cys), member 10
UniProt Protein Name:C-X-C motif chemokine 10
UniProt Synonym Protein Names:10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10Cleaved into the following chain:CXCL10(1-73)
UniProt Gene Name:CXCL10��
UniProt Entry Name:CXL10_HUMAN
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