Immunology Recombinant Proteins
Human Interleukin-4/IL-4 Recombinant Protein (RPES3551)
- SKU:
- RPES3551
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immunology
Description
Human Interleukin-4/IL-4 Recombinant Protein
Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates a wide range of T and B cell responses, including cell proliferation, survival, and gene expression. IL-4 is made by mast cells, T cells, and bone marrow stromal cells. IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells; characterized by their cytokine-secretion profile that includes secretion of IL-4; IL-5; IL-6; IL-10; and IL-13; which favor a humoral immune response. IL-4 has a significant influence on the switching of immunoglobulins to the IgG1 and IgE isotypes. Excessive Th2 cell IL-4 activity has been linked to increased IgE production and an allergic response. Human Interleukin-4/IL-4 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | Human Interleukin-4/IL-4 Recombinant Protein (RPES3551) |
| Product Code: | RPES3551 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Interleukin-4, IL-4, B-Cell Stimulatory Factor 1, BSF-1, Binetrakin, Lymphocyte Stimulatory Factor 1, Pitrakinra, IL4 |
| Accession: | P05112 |
| Sequence: | His25-Ser153 |
| Activity: | Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.01-0.05 ng/ml. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Interleukin-4 is produced by our Mammalian expression system and the target gene encoding His25-Ser153 is expressed. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 14.97 kDa |
| AP Mol Mass: | 18 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM PB; 150mM NaCl; pH 7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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