Growth Factors & Cytokines Recombinant Proteins
Human Interleukin-31/IL-31 Recombinant Protein (RPES2376)
- SKU:
- RPES2376
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Growth Factors & Cytokines
Description
Human Interleukin-31/IL-31 Recombinant Protein
Interleukin 31 (IL-31) is a cytokine with a four-helix bundle structure. It has structural and functional similarities to IL-6, Oncostatin M, LIF, and Cardiotrophin-1. The human IL-31 gene encodes a precursor of 164 amino acids that includes a 23 amino acid signal peptide and a 141 amino acid mature protein. IL-31 has human and murine homologues with a sequence identity of 24 percent in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2). The IL-31 signaling pathway is activated by the heterodimeric receptor complex consisting of an IL-31RA (also known as GPL and GLMR) protein and an Oncostatin M receptor (OSM R-beta). Keratinocytes express the IL-31 receptor in a permanent manner and can be induced by IFN gamma on monocytes. GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulates immune responses that are linked with skin physiology and inflammatory skin diseases. Studies have shown that IL31 induces severe pruritis (itching) and dermatitis in transgenic mice. Human Interleukin-31/IL-31 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | Human Interleukin-31/IL-31 Recombinant Protein (RPES2376) |
| Product Code: | RPES2376 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | E.coli |
| Synonyms: | Interleukin-31, IL-31, IL31 |
| Accession: | Q6EBC2 |
| Sequence: | Ser24-Thr164 |
| Fusion tag: | |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Interleukin-31 is produced by our E.coli expression system and the target gene encoding Ser24-Thr164 is expressed. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 15.8 kDa |
| AP Mol Mass: | 15 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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