Hormones Recombinant Proteins

Human INHBC Recombinant Protein (RPPB1285)

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SKU:
RPPB1285
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P55103
Research Area:
Hormones

Description

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Product Name:Human INHBC Recombinant Protein
Product Code:RPPB1285
Size:10µg
Species:Human
Target:INHBC
Synonyms:Inhibin Beta C, Actv Beta-C Chain, IHBC, Inhibin Beta C Chain.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The INHBC solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSGIDCQGG SRMCCRQEFF VDFREIGWHD WIIQPEGYAM NFCIGQCPLH IAGMPGIAAS FHTAVLNLLK ANTAAGTTGG GSCCVPTARR PLSLLYYDRD SNIVKTDIPD MVVEACGCS�

INHBC, the beta C chain of inhibin, belongs to the TGF-beta superfamily. INHBC formulates heterodimers with beta A and beta B subunits. Other members of the TGF-beta superfamily are Actv's and Inhibins, hormones with contradictory roles which take part in pituitary, hypothalamic, and gonadal hormone secretion, as well as differentiation and growth of numerous cell types.

INHBC Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 139 amino acids (237-352) and having a molecular mass of 14.9kDa.INHBC is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:INHBC: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: extracellular region; extracellular space

Molecular Function:cytokine activity; growth factor activity; hormone activity; transforming growth factor beta receptor binding

Biological Process: cell development; regulation of apoptosis; regulation of MAPKKK cascade

NCBI Summary:This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types. [provided by RefSeq, Jul 2008]
UniProt Code:P55103
NCBI GenInfo Identifier:1708438
NCBI Gene ID:3626
NCBI Accession:P55103.1
UniProt Secondary Accession:P55103,A1L3Y2,
UniProt Related Accession:P55103
Molecular Weight:38,238 Da
NCBI Full Name:Inhibin beta C chain
NCBI Synonym Full Names:inhibin beta C
NCBI Official Symbol:INHBC��
NCBI Official Synonym Symbols:IHBC��
NCBI Protein Information:inhibin beta C chain
UniProt Protein Name:Inhibin beta C chain
UniProt Synonym Protein Names:Activin beta-C chain
Protein Family:Inhibin
UniProt Gene Name:INHBC��
UniProt Entry Name:INHBC_HUMAN
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