Human ING2 Recombinant Protein (RPPB3751)
- SKU:
- RPPB3751
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9H160
Description
| Product Name: | Human ING2 Recombinant Protein |
| Product Code: | RPPB3751 |
| Size: | 20µg |
| Species: | Human |
| Target: | ING2 |
| Synonyms: | Inhibitor Of Growth Family Member 2, ING1L, Inhibitor Of Growth 1-Like Protein, P33ING2, ING1Lp, P32, Inhibitor Of Growth Family Member 1-Like, Inhibitor Of Growth Protein 2, ING2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | ING2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMLGQQQQ QLYSSAALLT GERSRLLTCY VQDYLECVES LPHDMQRNVS VLRELDNKYQ ETLKEIDDVY EKYKKEDDLN QKKRLQQLLQ RALINSQELG DEKIQIVTQM LELVENRARQ MELHSQCFQD PAESERASDK AKMDSSQPER SSRRPRRQRT SESRDLCHMA NGIEDCDDQP PKEKKSKSAK KKKRSKAKQE REASPVEFAI DPNEPTYCLC NQVSYGEMIG CDNEQCPIEW FHFSCVSLTY KPKGKWYCPK CRGDNEKTMD KSTEKTKKDR RSR |
Inhibitor of Growth Family, Member 2 (ING2) belongs to the inhibitor of growth (ING) family. ING family members associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and serve in DNA repair and apoptosis. ING2 appears to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, most likely by enhancing acetylation of p53/TP53. ING2 is a component of an mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity is modulated by binding to phosphoinositides (PtdInsPs).
ING2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 303 amino acids (1-280 a.a) and having a molecular mass of 35.2kDa.ING2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ING2: Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). Belongs to the ING family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 4q35.1 Cellular Component: CCAAT-binding factor complex; cytoplasm; Golgi apparatus; nucleoplasm; nucleus; plasma membrane; Sin3 complex Molecular Function:DNA binding; methylated histone residue binding; phosphoinositide binding; protein binding; protein complex binding Biological Process: chromatin modification; male germ-line stem cell division; male meiosis I; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of transcription, DNA-dependent; signal transduction; sperm motility; spermatid development; spermatogenesis |
| NCBI Summary: | This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
| UniProt Code: | Q9H160 |
| NCBI GenInfo Identifier: | 59798471 |
| NCBI Gene ID: | 3622 |
| NCBI Accession: | Q9H160.2 |
| UniProt Secondary Accession: | Q9H160,O95698, B6ZDS1, |
| UniProt Related Accession: | Q9H160 |
| Molecular Weight: | 27,984 Da |
| NCBI Full Name: | Inhibitor of growth protein 2 |
| NCBI Synonym Full Names: | inhibitor of growth family member 2 |
| NCBI Official Symbol: | ING2�� |
| NCBI Official Synonym Symbols: | ING1L; p33ING2�� |
| NCBI Protein Information: | inhibitor of growth protein 2 |
| UniProt Protein Name: | Inhibitor of growth protein 2 |
| UniProt Synonym Protein Names: | Inhibitor of growth 1-like protein; ING1Lp; p32; p33ING2 |
| Protein Family: | Inhibitor of growth protein |
| UniProt Gene Name: | ING2�� |
| UniProt Entry Name: | ING2_HUMAN |
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