Human IMPACT Recombinant Protein (RPPB3742)

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SKU:
RPPB3742
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9P2X3

Description

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Product Name:Human IMPACT Recombinant Protein
Product Code:RPPB3742
Size:20µg
Species:Human
Target:IMPACT
Synonyms:RWDD5, Protein IMPACT, Imprinted and ancient gene protein homolog, IMPACT.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:IMPACT protein solution (1mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAEGDAG SDQRQNEEIE AMAAIYGEEW CVIDDCAKIF CIRISDDIDD PKWTLCLQVM LPNEYPGTAP PIYQLNAPWL KGQERADLSN SLEEIYIQNI GESILYLWVE KIRDVLIQKS QMTEPGPDVK KKTEEEDVEC EDDLILACQP ESSVKALDFD ISETRTEVEV EELPPIDHGI PITDRRSTFQ AHLAPVVCPK QVKMVLSKLY ENKKIASATH NIYAYRIYCE DKQTFLQDCE DDGETAAGGR LLHLMEILNV KNVMVVVSRW YGGILLGPDR FKHINNCARN ILVEKNYTNS PEESSKALGK NKKVRKDKKR NEH

Impact RWD Domain Protein (IMPACT) is a member of the IMPACT family which is comprised of 1 RWD domain. IMPACT is a translational regulator which certifies constant high levels of translation under amino acid starvation. IMPACT interacts with GCN1/GCN1L1, thus preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. IMPACT is highly expressed especially in brain.

IMPACT Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 343 amino acids (1-320 a.a.) and having a molecular mass of 38.9kDa.IMPACT is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:IMPACT: Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. Belongs to the IMPACT family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 18q11.2-q12.1

Cellular Component: polysome

Biological Process: cellular response to amino acid starvation; cellular response to glucose starvation; negative regulation of protein amino acid autophosphorylation; negative regulation of protein amino acid phosphorylation; negative regulation of protein complex assembly; negative regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation

UniProt Code:Q9P2X3
NCBI GenInfo Identifier:296434540
NCBI Gene ID:55364
NCBI Accession:Q9P2X3.2
UniProt Secondary Accession:Q9P2X3,Q49AM0, Q9H2X4, A8MXG0,
UniProt Related Accession:Q9P2X3
Molecular Weight:22,999 Da
NCBI Full Name:Protein IMPACT
NCBI Synonym Full Names:impact RWD domain protein
NCBI Official Symbol:IMPACT��
NCBI Official Synonym Symbols:RWDD5��
NCBI Protein Information:protein IMPACT
UniProt Protein Name:Protein IMPACT
UniProt Synonym Protein Names:Imprinted and ancient gene protein homolog
Protein Family:IMPACT family
UniProt Gene Name:IMPACT��
UniProt Entry Name:IMPCT_HUMAN
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