Enzymes Recombinant Proteins

Human IMMP2L Recombinant Protein (RPPB1847)

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SKU:
RPPB1847
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q96T52
Research Area:
Enzymes

Description

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Product Name:Human IMMP2L Recombinant Protein
Product Code:RPPB1847
Size:20µg
Species:Human
Target:IMMP2L
Synonyms:IMP2 Inner Mitochondrial Membrane Peptidase-Like (S.Cerevisiae), IMP2, IMP2 Inner Mitochondrial Membrane Protease-Like (S.Cerevisiae), IMMP2L Intronic Transcript 1 (Non-Protein Coding), MitochondrialInner Membrane Protease Subunit, Inner Mitochondrial Membrane Peptidase 2 Like,IMP2-Like Protein, EC 3.4.21.- , IMMP2L-IT1,IMP2-LIKE, EC 3.4.21, Mitochondrial inner membraneprotease subunit 2.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:IMMP2L protein solution (0.5mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.15M NaCl, 50% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSRVEGASM QPSLNPGGSQ SSDVVLLNHW KVRNFEVHRG DIVSLVSPKNPEQKIIKRVI ALEGDIVRTI GHKNRYVKVP RGHIWVEGDH HGHSFDSNSF GPVSLGLLHA HATHILWPPERWQKLESVLP PERLPVQREE E

IMP2 Inner Mitochondrial Membrane Peptidase-Like (IMMP2L) is implicatedin processing the signal peptide sequences, IMMP2L is used to directmitochondrial proteins to� the mitochondria. IMMP2Lresides in the mitochondria and is one of the essential proteins for the catalyticactivity of the mitochondrial inner membrane peptidase (IMP) complex. Twovariants which encode the same protein have been found for IMMP2L.

IMMP2L Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 161 amino acids (38-175aa) andhaving a molecular mass of 18.0kDa.�IMMP2L is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:IMMP2L: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO. Defects in IMMP2L may be a cause of Gilles de la Tourette syndrome (GTS). GTS is a neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities. Belongs to the peptidase S26 family. IMP2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.4.21.-; Mitochondrial; Membrane protein, integral; ProteaseChromosomal Location of Human Ortholog: 7q31Molecular Function: peptidase activity; serine-type endopeptidase activityBiological Process: mitochondrial protein processing; mitochondrial respiratory chain complex assembly; signal peptide processing
UniProt Protein Details:
NCBI Summary:This gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex. Two variants that encode the same protein have been described for this gene. [provided by RefSeq, Sep 2011]
UniProt Code:Q96T52
NCBI GenInfo Identifier:74752143
NCBI Gene ID:83943
NCBI Accession:Q96T52.1
UniProt Secondary Accession:Q96T52,Q75MF1, Q75MN9, Q75MP0, Q75MS5, Q75MS8, Q96HJ2
UniProt Related Accession:Q96T52
Molecular Weight:12,259 Da
NCBI Full Name:Mitochondrial inner membrane protease subunit 2
NCBI Synonym Full Names:inner mitochondrial membrane peptidase subunit 2
NCBI Official Symbol:IMMP2L��
NCBI Official Synonym Symbols:IMP2; IMP2-LIKE; IMMP2L-IT1��
NCBI Protein Information:mitochondrial inner membrane protease subunit 2
UniProt Protein Name:Mitochondrial inner membrane protease subunit 2
UniProt Synonym Protein Names:IMP2-like protein
Protein Family:
UniProt Gene Name:IMMP2L��
UniProt Entry Name:IMP2L_HUMAN
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