Human ILRA/IL1RN Recombinant Protein (RPES0276)

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SKU:
RPES0276
Product Type:
Recombinant Protein
Species:
Human

Description

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Human ILRA/IL1RN Recombinant Protein

Interleukin-1 receptor antagonist (IL-1RA) is a type of interleukin 1 cytokine. Interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B) are inhibited by this protein, which also affects a variety of interleukin 1-related immune and inflammatory processes. The variant in the gene encoding this protein is believed to be linked to an increased risk of osteoporotic fractures and gastric cancer. IL-1RA/IL1RN may inhibit the activity of IL-1 by binding to its receptor and it has no IL-1 like activity. The presence of variation in the genes IL-1RA and IL1RN is linked to diabetic microvascular disease susceptibility (MVCD4). Diabetes mellitus causes a plethora of problems, the most serious of which are listed below. Diabetic retinopathy, diabetic nephropathy causing end-stage renal disease, and diabetic neuropathy are examples. Diabetic retinopathy is the leading cause of new-onset blindness in people with diabetes. It is characterized by a state of vascular permeability, which leads to enhanced tissue ischemia and angiogenesis. The deficiency of interleukin 1 receptor antagonist (DIRA) is caused by defects in IL-1RA/IL1RN. Without proof of infection, autoinflammatory diseases show inflammatory signs without evidence of illness; high-titer autoantibodies or autoreactive T-cells. DIRA is a rare; autosomal recessive; genetic autoinflammatory disease that results in sterile multifocal osteomyelitis; and pustulosis from birth. Human ILRA/IL1RN Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.

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