Human IL5RA/IL-5 R Alpha Recombinant Protein (RPES2522)

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SKU:
RPES2522
Product Type:
Recombinant Protein
Species:
Human

Description

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Human IL5RA/IL-5 R Alpha Recombinant Protein

Interleukin-5 Receptor alpha (IL-5R?; CD125) is a 60 kDa hematopoietin receptor that plays a dominant role in eosinophil biology. Mature human IL-5 R? consists of a 322 aa extracellular domain (ECD) with a WSxWS motif and a four cysteine motif; a 20 aa transmembrane segment; and a 58 aa cytoplasmic domain. Within the ECD; human IL-5R? shares 71% aa sequence identity with mouse and rat IL-5 R?. Alternate splicing of human IL-5 R? generates soluble secreted forms which function as IL-5 antagonists. The high affinity receptor for IL-5 is a complex that consists of the ligand binding IL-5 R? and the transmembrane common β chain (βc/CD131) which is shared with the receptor complexes for IL-3 and GMCSF. IL-5 R? binds IL-5 at low affinity and then associates with preformed βc oligomers to form the signaling competent receptor complex. IL-5 stimulation of CD34+ hematopoietic progenitor cells induces the up-regulation of transmembrane IL-5R? followed by eosinophilic differentiation and activation.

Product Name:Human IL5RA/IL-5 R Alpha Recombinant Protein (RPES2522)
Product Code:RPES2522
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Interleukin-5 receptor subunit alpha, IL-5 receptor subunit alpha, IL-5R subunit alpha, IL-5R-alpha, IL-5RA, CDw125, CD125, IL5RA, IL5R,HSIL5R3,IL5R
Accession:Q01344
Sequence:Asp21-Glu335
Fusion tag:C-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Interleukin-5 Receptor Subunit Alpha is produced by our Mammalian expression system and the target gene encoding Asp21-Glu335 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:36.7 kDa
AP Mol Mass:38-42 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of PBS; pH7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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