Immune Checkpoint Recombinant Proteins
Human IL4RA Recombinant Protein (hFc Tag) (HDPT0209)
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- SKU:
- HDPT0209
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immune Checkpoint
Description
Human IL4RA Recombinant Protein (hFc Tag)
| Description: | This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. |
| Product name: | Human IL4RA Recombinant Protein (hFc Tag) |
| Synonyms: | CD124; IL-4RA; IL4RA |
| Type: | protein |
| Size: | 50 µg |
| Name: | IL4RA |
| Origin: | Human |
| Source: | HEK293 |
| Protein Type: | Recombinant |
| Application: | Contact Technical Support |
| Purity: | Contact Technical Support |
| Purification: | affinity purification |
| Format: | Lyophilized |
| Conjugate: | C-Human Fc |
| Storage: | Store at -80°C for 12 months (Avoid repeated freezing and thawing) |
| Usage: | Research use only |
| Buffer: | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization. |
| Reconstitution: | Reconstitute with deionized water |
| Sequence: | IL4RA(Met26-His232)+hFc(Glu99-Ala330) |
| Gene ID: | |
| Uniprot: | P24394 |
| Molecular Weight: | 48.29 kDa |
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