Immune Checkpoint Recombinant Proteins

Human IL4RA Recombinant Protein (hFc Tag) (HDPT0209)

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SKU:
HDPT0209
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immune Checkpoint

Description

Human IL4RA Recombinant Protein (hFc Tag)

Description:This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
Product name:Human IL4RA Recombinant Protein (hFc Tag)
Synonyms:CD124; IL-4RA; IL4RA
Type:protein
Size:50 µg
Name:IL4RA
Origin:Human
Source:HEK293
Protein Type:Recombinant
Application:Contact Technical Support
Purity:Contact Technical Support
Purification:affinity purification
Format:Lyophilized
Conjugate:C-Human Fc
Storage:Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage:Research use only
Buffer:Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Reconstitution:Reconstitute with deionized water
Sequence:IL4RA(Met26-His232)+hFc(Glu99-Ala330)
Gene ID:
Uniprot:P24394
Molecular Weight:48.29 kDa
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