Human IL36G/IL1F9 Recombinant Protein (RPES2420)

Human IL36G/IL1F9 Recombinant Protein

Interleukin-36 gamma (IL-36 gamma) is a member of the interleukin 1 cytokine family that includes three closely related genes, IL-36 alpha, beta, and gamma, formerly known as IL-1F6, F8, and F9 respectively. The cytokine IL-36 alpha has been found in both neuronal and synovial tissue, whereas IL-36 beta and IL-36 gamma are expressed in both cutaneous and mucosal epithelial cells, including the respiratory tract. IL-36 beta and IL-36 gamma stimulate proliferation, maturation, and/or cytokine expression by innate immune cells (keratinocytes and dendritic cells) as well as adaptive immune cells (neutrophils and T-cells) in both humans and mice. Interleukin 36 alpha's activity is regulated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and it is specifically suppressed by interleukin 1 family, member 5 (IL1F5/IL-1 delta). IL-36-gamma plays an important role in communicating the cell death to surrounding cells. Human IL36G/IL1F9 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.