Cytokines Recombinant Proteins

Human IL1R1 Recombinant Protein (RPPB0477)

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SKU:
RPPB0477
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P14778
Research Area:
Cytokines

Description

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Product Name:Human IL1R1 Recombinant Protein
Product Code:RPPB0477
Size:10µg
Species:Human
Target:IL1R1
Synonyms:Interleukin-1 receptor type 1, IL1R1, Interleukin-1 receptor type 1, IL-1R-1, IL-1RT-1,IL-1RT1, CD121 antigen-like family member A, Interleukin-1 receptor alpha, IL-1R-alpha, Interleukin-1 receptor type I, p80, CD121a, Interleukin-1 receptor type 1, membrane form, mIL-1R1, mIL-1RI, Interleukin-1 receptor type 1, soluble form, sIL-1R1, sIL-1RI, IL1R, IL1RA, IL1RT1, IL1R1, IL1R1, CD121A, D2S1473.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:IL1R1 protein solution (0.25mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:DKCKEREEKI ILVSSANEID VRPCPLNPNE HKGTITWYKD DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN SSYCLRIKIS AKFVENEPNL CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN ENNELPKLQW YKDCKPLLLD NIHFSGVKDR LIVMNVAEKH RGNYTCHASY TYLGKQYPIT RVIEFITLEE NKPTRPVIVS PANETMEVDL GSQIQLICNV TGQLSDIAYW KWNGSVIDED DPVLGEDYYS VENPANKRRS TLITVLNISE IESRFYKHPF TCFAKNTHGI DAAYIQLIYP VTNFQKLEHH HHHH

Interleukin-1 receptor type 1 (IL1R1) associates with the co-receptor IL1RAP to form the high affinity interleukin-1 receptor complex, which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. IL1R1 is a central mediator involved in numerous cytokine induced immune and inflammatory responses.

IL1R1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 324 amino acids (21-336a.a.) and having a molecular mass of 37.4kDa(Migrates at 40-57kDa on SDS-PAGE under reducing conditions).IL1R1 is fused to 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:IL-1RA: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Belongs to the interleukin-1 receptor family.
UniProt Protein Details:

Protein type:EC 2.7.11.25; Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 2q12

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function:interleukin-1 receptor activity; platelet-derived growth factor receptor binding; protein binding; signal transducer activity; transmembrane receptor activity

Biological Process: cell surface receptor linked signal transduction; immune response

NCBI Summary:This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
UniProt Code:P14778
NCBI GenInfo Identifier:124308
NCBI Gene ID:3554
NCBI Accession:P14778.1
UniProt Secondary Accession:P14778,Q587I7,
UniProt Related Accession:P14778
Molecular Weight:65,402 Da
NCBI Full Name:Interleukin-1 receptor type 1
NCBI Synonym Full Names:interleukin 1 receptor type 1
NCBI Official Symbol:IL1R1��
NCBI Official Synonym Symbols:P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha��
NCBI Protein Information:interleukin-1 receptor type 1
UniProt Protein Name:Interleukin-1 receptor type 1
UniProt Synonym Protein Names:CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha
Protein Family:Interleukin-1 receptor
UniProt Gene Name:IL1R1��
UniProt Entry Name:IL1R1_HUMAN
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