Cytokines Recombinant Proteins

Human IL18RAP Recombinant Protein (RPPB0626)

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SKU:
RPPB0626
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O95256
Research Area:
Cytokines

Description

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Product Name:Human IL18RAP Recombinant Protein
Product Code:RPPB0626
Size:5µg
Species:Human
Target:IL18RAP
Synonyms:Interleukin-18 receptor accessory protein, IL-18 receptor accessory protein, IL-18RAcP, Accessory protein-like, AcPL, CD218 antigen-like family member B, CDw218b, IL-1R accessory protein-like, IL-1RAcPL, Interleukin-1 receptor 7, IL-1R-7, IL-1R7, Interleukin-18 receptor accessory protein-like, Interleukin-18 receptor beta, IL-18R-beta, IL-18Rbeta, CD218b, IL1R7.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:IL18RAP protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) AND 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:FNISGCSTKK LLWTYSTRSE EEFVLFCDLP EPQKSHFCHR NRLSPKQVPE HLPFMGSNDL SDVQWYQQPS NGDPLEDIRK SYPHIIQDKC TLHFLTPGVN NSGSYICRPK MIKSPYDVAC CVKMILEVKP QTNASCEYSA SHKQDLLLGS TGSISCPSLS CQSDAQSPAV TWYKNGKLLS VERSNRIVVD EVYDYHQGTY VCDYTQSDTV SSWTVRAVVQ VRTIVGDTKL KPDILDPVED TLEVELGKPL TISCKARFGF ERVFNPVIKW YIKDSDLEWE VSVPEAKSIK STLKDEIIER NIILEKVTQR DLRRKFVCFV QNSIGNTTQS VQLKEKRLEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH

Interleukin-18 receptor accessory protein (IL18RAP), belongs to the IL-1 family of cytokines which holds multiple immunoregulatory functions. It has been found that IL18RAP does not mediate IL18-binding, however, IL18RAP is involved in IL18-dependent signal transduction, which leads to NF-kappa-B and JNK activation. IL18R1 as well as IL18RAP polymorphisms have been linked with the following diseases: schizophrenia, HSV1 seropositivity and atopic asthma.

IL18RAP produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 576 amino acids (20-356 a.a.) and having a molecular mass of 65.4kDa (Molecular size on SDS-PAGE will appear at approximately 70-100kDa).IL18RAP is expressed with an 239 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:IL18RAP: Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Belongs to the interleukin-1 receptor family.Protein type: Cell surface; Membrane protein, integralChromosomal Location of Human Ortholog: 2q12Cellular Component: integral to membraneMolecular Function: receptor activityBiological Process: cell surface receptor linked signal transduction; immune response; inflammatory response
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
UniProt Code:O95256
NCBI GenInfo Identifier:74762124
NCBI Gene ID:8807
NCBI Accession:O95256.1
UniProt Secondary Accession:O95256,Q3KPE7, Q3KPE8, Q53TT4, Q53TU5, B2RPJ3
UniProt Related Accession:O95256
Molecular Weight:599
NCBI Full Name:Interleukin-18 receptor accessory protein
NCBI Synonym Full Names:interleukin 18 receptor accessory protein
NCBI Official Symbol:IL18RAP��
NCBI Official Synonym Symbols:ACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta��
NCBI Protein Information:interleukin-18 receptor accessory protein; IL-18 receptor beta; interleukin-1 receptor 7; interleukin-18 receptor beta; IL-18 receptor accessory protein; cluster of differentiation w218b; CD218 antigen-like family member B
UniProt Protein Name:Interleukin-18 receptor accessory protein
UniProt Synonym Protein Names:Accessory protein-like; AcPL; CD218 antigen-like family member B; CDw218b; IL-1R accessory protein-like; IL-1RAcPL; Interleukin-1 receptor 7; IL-1R-7; IL-1R7; Interleukin-18 receptor accessory protein-like; Interleukin-18 receptor beta; IL-18R-beta; IL-18Rbeta; CD_antigen: CD218b
Protein Family:
UniProt Gene Name:IL18RAP��
UniProt Entry Name:I18RA_HUMAN
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