Human IL17RA Recombinant Protein (RPES3390)
- SKU:
- RPES3390
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
system_update_altDatasheet
Human IL17RA Recombinant Protein
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors; this receptor likely has a multimeric structure.
| Product Name: | Human IL17RA Recombinant Protein (RPES3390) |
| Product Code: | RPES3390 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | CD127,CDW127,IL-17R,IL-17R-alpha,IL7RA,ILRA, IL-17RA, IL-17 R alpha, Interleukin-17 receptor A |
| Accession: | NP_055154.3 |
| Sequence: | Leu33-Trp320 |
| Fusion tag: | C-Fc |
| Activity: | Measured by its ability to inhibit IL-17-induced IL-6 secretion by NIH?3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 20-100 ng/ml. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Interleukin-17 receptor A is produced by our Mammalian expression system and the target gene encoding Leu33-Trp320 is expressed with a Fc tag at the C-terminus. |
| Purity: | > 90 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 60.6 kDa |
| AP Mol Mass: | 90-120 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS; pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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