Cytokines Recombinant Proteins

Human IL13RA2 Recombinant Protein (RPPB0583)

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SKU:
RPPB0583
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q14627
Research Area:
Cytokines

Description

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Product Name:Human IL13RA2 Recombinant Protein
Product Code:RPPB0583
Size:10µg
Species:Human
Target:IL13RA2
Synonyms:CD213A2, CT19, IL-13R, IL13BP, IL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, CD_antigen=CD213a2, Interleukin-13-binding protein.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:IL 13RA2 protein solution (0.5mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADLDTEIKVN PPQDFEIVDP GYLGYLYLQW QPPLSLDHFK ECTVEYELKY RNIGSETWKT IITKNLHYKD GFDLNKGIEA KIHTLLPWQC TNGSEVQSSW AETTYWISPQ GIPETKVQDM DCVYYNWQYL LCSWKPGIGV LLDTNYNLFY WYEGLDHALQ CVDYIKADGQ NIGCRFPYLE ASDYKDFYIC VNGSSENKPI RSSYFTFQLQ NIVKPLPPVY LTFTRESSCE IKLKWSIPLG PIPARCFDYE IEIREDDTTL VTATVENETY TLKTTNETRQ LCFVVRSKVN IYCSDDGIWS EWSDKQCWEG EDLSKKTLLR LEPKSCDKTH TCPPCPAPEL LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS RDELTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHNHYTQKSLSLS PGKHHHHHH

Interleukin 13 Receptor, Alpha 2 (IL13RA2) is a member of the type I cytokine receptor family, Type 5 subfamily. IL13RA2 is related to l13RA1, a subunit of the interleukin 13 receptor complex. IL13RA2 binds IL13 with high affinity, though lacking the cytoplasmic domain, and does not appear to function as a signal mediator. IL13RA2 plays a role in the internalization of IL13.

IL13RA2 Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 559 amino acids (27-343 a.a.) and having a molecular mass of 64.3kDa (Molecular size on SDS-PAGE will appear at approximately 70-100kDa). IL13RA2 is expressed with a 239 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:IL13RA2: a type I membrane protein that binds with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). Lacks a cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. A member of the Cancer-Testis Antigen (CTA) superfamily. CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovarian cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation. Often overexpressed in brain tumors. A potential vaccine targets for immunotherapy of glioma. Note: This description may include information from RefSeq and UniProtKB
UniProt Protein Details:

Protein type:Membrane protein, integral; Cancer Testis Antigen (CTA); Receptor, cytokine

Chromosomal Location of Human Ortholog: Xq23

Cellular Component: extracellular space; integral to membrane

Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; signal transducer activity

Biological Process: cytokine and chemokine mediated signaling pathway; signal transduction

NCBI Summary:The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]
UniProt Code:Q14627
NCBI GenInfo Identifier:2494720
NCBI Gene ID:3598
NCBI Accession:Q14627.1
UniProt Secondary Accession:Q14627,O00667, A8K7E2,
UniProt Related Accession:Q14627
Molecular Weight:380
NCBI Full Name:Interleukin-13 receptor subunit alpha-2
NCBI Synonym Full Names:interleukin 13 receptor, alpha 2
NCBI Official Symbol:IL13RA2��
NCBI Official Synonym Symbols:CT19; IL-13R; IL13BP; CD213A2��
NCBI Protein Information:interleukin-13 receptor subunit alpha-2; IL-13RA2; IL-13R-alpha-2; IL-13R subunit alpha-2; cancer/testis antigen 19; IL-13 receptor subunit alpha-2; interleukin 13 binding protein; interleukin-13-binding protein; interleukin 13 receptor alpha 2 chain
UniProt Protein Name:Interleukin-13 receptor subunit alpha-2
UniProt Synonym Protein Names:Interleukin-13-binding protein; CD_antigen: CD213a2
Protein Family:Interleukin-13 receptor
UniProt Gene Name:IL13RA2��
UniProt Entry Name:I13R2_HUMAN
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