Cytokines Recombinant Proteins

Human IL-9 Recombinant Protein (RPPB0548)

(No reviews yet) Write a Review
SKU:
RPPB0548

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human IL-9 Recombinant Protein
Product Code:RPPB0548
Size:10µg
Species:Human
Target:IL-9
Synonyms:Interleukin 9, Protein Il9, Il9, HP40, Cytokine P40, T-cell growth factor P40
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The IL-9 �solution (0.5mg/ml) contains 10% Glycerol and Phosphate-Buffered Saline (pH 7.4).
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:QGCPTLAGIL DINFLINKMQ EDPASKCHCS ANVTSCLCLG IPSDNCTRPC FSERLSQMTNTTMQTRYPLI FSRVKKSVEV LKNNKCPYFS CEQPCNQTTA GNALTFLKSL LEIFQKEKMR GMRGKIHHHH HH
Biological Activity:Determined by cell proliferation assay using MO7e human megakaryocytic leukemic cells. ED50 range for this effect is ? 0.3 ng/ml.

Interleukin-9 is a protein that acts as one of the regulators of hematopoiesis. IL-9 is an enhancer of cells and megakaryoblastic leukemic cells� growth. Among this protein�s producers we can find cells like mast cells, Treg, NKT cells, Th17, Th2, ILC2, and Th9 cells in various amounts. Th9 are the primary CD4 cells (T cells) that IL-9 is produced in.

IL-9 Human produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 132 amino acids (19-144 aa) and having a molecular mass of 14.9kDa.IL-9 is fused to a 6 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:IL9: Supports IL-2 independent and IL-4 independent growth of helper T-cells. Belongs to the IL-7/IL-9 family.
UniProt Protein Details:

Protein type:Secreted; Cytokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular space

Molecular Function:growth factor activity; interleukin-9 receptor binding; cytokine activity

Biological Process: positive regulation of cell proliferation; immune response; inflammatory response; positive regulation of cell growth; positive regulation of interleukin-5 biosynthetic process

NCBI Summary:The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008]
UniProt Code:P15248
NCBI GenInfo Identifier:124362
NCBI Gene ID:3578
NCBI Accession:P15248.1
UniProt Related Accession:P15248
Molecular Weight:15kDa
NCBI Full Name:Interleukin-9
NCBI Synonym Full Names:interleukin 9
NCBI Official Symbol:IL9��
NCBI Official Synonym Symbols:P40; HP40; IL-9��
NCBI Protein Information:interleukin-9; cytokine P40; p40 cytokine; T-cell growth factor p40; p40 T-cell and mast cell growth factor; homolog of mouse T cell and mast cell growth factor 40
UniProt Protein Name:Interleukin-9
UniProt Synonym Protein Names:Cytokine P40; T-cell growth factor P40
Protein Family:Interleukin
UniProt Gene Name:IL9��
UniProt Entry Name:IL9_HUMAN
View AllClose

Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P15248
Research Area:
Cytokines
View AllClose

Related Products