Cytokines Recombinant Proteins

Human IL 7 Recombinant Protein (RPPB0540)

(No reviews yet) Write a Review
SKU:
RPPB0540
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P13232
Research Area:
Cytokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human IL 7 Recombinant Protein
Product Code:RPPB0540
Size:10µg
Species:Human
Target:IL 7
Synonyms:Lymphopoietin 1 (LP-1), pre-B cell factor, IL-7.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:Interleukin -7 His is supplied in 1x PBS and 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.

Interleukin-7 is a potent lymphoid cell growth factor produced primarily by stromal cells.IL-7 has been shown to support the proliferation and differentiation of pre B- and early T cells as well as displaying a biological effect on cells of NK and myeloid lineages.

IL-7 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 152 amino acids fragment (26-177) and having a total molecular mass of 21.97 kDa with an amino-terminal hexahistidine tag. The IL-7 His-Tag protein is purified by proprietary chromatographic techniques.

UniProt Protein Function:IL7: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Apoptosis; Secreted, signal peptide; Cell development/differentiation; Cytokine; Secreted; Cell cycle regulation

Chromosomal Location of Human Ortholog: 8q12-q13

Cellular Component: extracellular space; extracellular region

Molecular Function:interleukin-7 receptor binding; protein binding; growth factor activity; cytokine activity

Biological Process: positive regulation of organ growth; humoral immune response; T cell lineage commitment; organ morphogenesis; positive regulation of T cell differentiation; cell-cell signaling; regulation of gene expression; homeostasis of number of cells within a tissue; negative regulation of catalytic activity; positive regulation of cell proliferation; positive regulation of B cell proliferation; negative regulation of apoptosis; bone resorption

NCBI Summary:The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]
UniProt Code:P13232
NCBI GenInfo Identifier:124354
NCBI Gene ID:3574
NCBI Accession:P13232.1
UniProt Secondary Accession:P13232,Q5FBY5, Q5FBY9, A0N0L3,
UniProt Related Accession:P13232
Molecular Weight:177
NCBI Full Name:Interleukin-7
NCBI Synonym Full Names:interleukin 7
NCBI Official Symbol:IL7��
NCBI Official Synonym Symbols:IL-7��
NCBI Protein Information:interleukin-7
UniProt Protein Name:Interleukin-7
Protein Family:Interleukin
UniProt Gene Name:IL7��
UniProt Entry Name:IL7_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products