Cytokines Recombinant Proteins

Human IL 33 Recombinant Protein (RPPB0664)

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RPPB0664

Description

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Product Name:Human IL 33 Recombinant Protein
Product Code:RPPB0664
Size:10µg
Species:Human
Target:IL 33
Synonyms:Interleukin 33, DVS27, NF-HEV, NKHEV, C9orf26, Interleukin-1 family member 11, IL- 1F11, Nuclear factor from high endothelial venules, NFEHEV, DKFZp586H0523, RP11-575C20.2, IL-33, IL33.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:Interleukin-33 protein solution is supplied in 10mM Tris-HCl pH 8.0, 180mM NaCl and 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.

Interleukin 33 (IL-33) is a 32kDa proinflammatory cytokine that may also regulate gene transcription in producer cells. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1.

Interleukin-33 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 159 amino acids C-terminal fragment (112-270) having a molecular weight of 22.49kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The IL-33 His is purified by proprietary chromatographic techniques.

UniProt Protein Function:IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cytokine

Chromosomal Location of Human Ortholog: 9p24.1

Cellular Component: extracellular space; transport vesicle; chromosome; nucleus

Molecular Function:protein binding; cytokine activity

Biological Process: T-helper 2 type immune response; negative regulation of T-helper 1 type immune response; positive regulation of T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of interleukin-6 production; positive regulation of immunoglobulin secretion; negative regulation of leukocyte migration; positive regulation of interleukin-4 production; negative regulation of immunoglobulin secretion; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of interferon-gamma production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; positive regulation of macrophage activation; positive regulation of inflammatory response

NCBI Summary:IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 [PubMed 20926795]).[supplied by OMIM, Jan 2011]
UniProt Code:O95760
NCBI GenInfo Identifier:68565855
NCBI Gene ID:90865
NCBI Accession:O95760.1
UniProt Secondary Accession:O95760,Q2YEJ5, B2R8L1, B4DJ35, B4E1Q9, D3DRI5, E7EAX4
UniProt Related Accession:O95760
Molecular Weight:16,250 Da
NCBI Full Name:Interleukin-33
NCBI Synonym Full Names:interleukin 33
NCBI Official Symbol:IL33��
NCBI Official Synonym Symbols:DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26��
NCBI Protein Information:interleukin-33; IL-33; IL-1F11; DVS27-related protein; interleukin-1 family member 11; nuclear factor for high endothelial venules; nuclear factor from high endothelial venules
UniProt Protein Name:Interleukin-33
UniProt Synonym Protein Names:Interleukin-1 family member 11; IL-1F11; Nuclear factor from high endothelial venules; NF-HEV
Protein Family:Interleukin
UniProt Gene Name:IL33��
UniProt Entry Name:IL33_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O95760
Research Area:
Cytokines
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