Human IL-22BP/IL-22RA2 Recombinant Protein (RPES3172)

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SKU:
RPES3172
Product Type:
Recombinant Protein
Species:
Human

Description

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Human IL-22BP/IL-22RA2 Recombinant Protein

Interleukin-22 Receptor Subunit ?-2 (IL22RA2) belongs to the type II cytokine receptor family. IL22RA2 is a secreted protein and contains three fibronectin type-III domains. IL22RA2 is widely expressed in many tissues. IL22RA2 functions as an IL22 antagonist and may be important in the regulation of inflammatory response. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Product Name:Human IL-22BP/IL-22RA2 Recombinant Protein (RPES3172)
Product Code:RPES3172
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Interleukin-22 Receptor Subunit Alpha-2, IL-22 Receptor Subunit Alpha-2, IL-22R-Alpha-2, IL-22RA2, Cytokine Receptor Class-II Member 10, Cytokine Receptor Family 2 Member 10, CRF2-10, Cytokine Receptor Family Type 2 Soluble 1, CRF2-S1, Interleukin-22-Binding Protein, IL-22BP, IL22BP, ZcytoR16, IL22RA2
Accession:Q969J5-2
Sequence:Thr 22-Pro231
Fusion tag:C-6His
Activity:Measured by its ability to inhibit IL-22-induced IL-10 secretion by COLO 205 human colorectal adenocarcinoma cells. The ED50 for this effect is typically 113.2 ng/ml in the presence of 500 ng/mL of Recombinant Human IL-22.
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Interleukin-22 receptor subunit alpha-2/Interleukin-22 Binding Protein is produced by our Mammalian expression system and the target gene encoding Thr22-Pro231 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:25.7 kDa
AP Mol Mass:44 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM PB;150mM NaCl;pH7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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